Skip to main content
Log in

Reference values for serum zinc and selenium of French healthy children

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

Age — and sex — specific reference intervals derived from a healthy pediatric population are presented for zinc, selenium and related analytes in serum. No strong correlations were found between age, sex and trace elements in serum. Serum variables were discussed to assess their ability as biochemical indicators of micronutrient status in the field of biological epidemiology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. AlfthanG. and KumpulainenJ. (1982): Determination of selenium in small volumes of blood plasma and serum by electrothermal atomic absorption spectrometry - Anal. Chim. Acta 140: 221–227.

    Google Scholar 

  2. ChaudièreJ., GérardD., ClémentM. and BourreJ.M. (1987): Induction of selenium glutathion peroxidase by stimulation of metabolic hydrogen peroxide production in vivo - Biochem. Bioenergetics 18: 247–256.

    Google Scholar 

  3. DawsonJ.B. and WalkerB.E. (1969): Direct determination of zinc in whole blood, plasma and urine by atomic absorption spectrophotometry - Clin. Chim. Acta 26: 465–475.

    Google Scholar 

  4. DoboisF., JebyA., BellevilleF., NabetP. and PaysantP. (1990): Valeurs usuelle du sélenium sérique dans une population de l'Est de la France - Ann. Biol. Clin. 48: 28–32.

    Google Scholar 

  5. Expert Scientific Working Group, Federation of American Societies for Experimental Biolog (1984): Assessment of the zinc nutritional status of the US population based on data collected in the Second National Health and Nutrition Examination Survey, 1976–1980, Bethesda, MD: LSRO.

    Google Scholar 

  6. FavierA. and RuffieuxD. (1983): Physiological variations of serum levels of copper, zinc, iron and manganese - Pharmacotherapy 37: 462–466.

    Google Scholar 

  7. GordonE.F., CordonR.C. and PassalD.B. (1981): Zinc metabolism: basic, clinical and behavioral aspects - J. Ped. 99: 341–349.

    Google Scholar 

  8. HambidgeK.M., WalravensP.A., BrownR.M., WebsterJ., WhiteS., AnthonyM. and RothM.L. (1976): Zinc nutrition of preschool children in the Denver Head Start program - Am. J. Clin. Nutr. 29: 734–738.

    Google Scholar 

  9. Institut National de la Statistique et des Etudes Economiques (1989): Bulletin Mensuel de Statistique, no 1.

  10. JonesR.B., KeelingP.W.N., HiltonP.J. and ThompsonR.P.H. (1981): The relationship between leukocyte and muscle zinc in health and disease - Clin. Sci. 60: 237–239.

    Google Scholar 

  11. KasperekK., FeinengedenL.E., LombeckI. and BremerH.J. (1977): Serum zinc concentration during childhood - Eur. J. Pediatr. 126: 199–202.

    Google Scholar 

  12. Keshan Disease Research Group of the Chinese Academy of Medical Sciences, Beijing (1980): Epidemiologic studies on the etiologic relationship of selenium and Keshan disease - Biol. Tr. El. Res. 2: 91–107.

    Google Scholar 

  13. LockitchG., HalsteadA.C., WadsworthL., QuigleyG., Reston L. and JacobsonB. (1988): Age- and sex-specific pediatric reference intervals and correlations for zinc, copper, selenium, iron, vitamins A and E, and related proteins - Clin. Chem. 34: 1625–1628.

    Google Scholar 

  14. LombeckI, KasperekK., HarbischH.D., FeinendegenL.E. and BremerH.J. (1977): The selenium state of healthy children - Eur. J. Pediatr. 125: 81–88.

    Google Scholar 

  15. MaranoG., SpagnoloA., MorisiG. and MenottiA. (1991): Changes of serum selenium and serum cholesterol in children during sexual maturation - J. Trace Elem. Electrolytes Health Dis. 5: 59–61.

    Google Scholar 

  16. Mc KenzieR.L., ReaH.M., ThompsonC.D. and RobinsonM.F. (1978): Selenium concentration and glutathione peroxidase activity in blood of New Zealand infants and children - Am. J. Clin. Nutr. 31: 1413–1418.

    Google Scholar 

  17. MeitesS., BuffoneG.J., ChengM.H., PesceM.A., SoldinS.J. and TurleyC.P. (1989): Pediatric clinical chemistry — Reference (normal) values (3rd ed.), Washington, DC 20006, AACC Press pp. 296–297.

    Google Scholar 

  18. MichaëlssonG., VahlquistA., JuhlinL., MellbinT. and BrattL. (1976): Zinc and vitamin A: serum concentrations of zinc and retinol-binding protein (RBP) in healthy adolescents - Scand. J. Clin. Lab. Invest. 36: 827–832.

    Google Scholar 

  19. NeveJ., VertongenF. and MolleL. (1985): Selenium deficiency - Clin. Endocrinol. Metab. 14: 629–656.

    Google Scholar 

  20. NeveJ., ChamartS. and MolleL. (1987): Optimisation of a direct procedure of selenium in plasma and erythrocytes using Zeeman effect atomic absorption spectroscopy, In: Trace element analytical chemistry in medicine and biology, ed. by Bratter P. and Schramel P., Berlin, Walter de Gruyter 4: 1–10.

    Google Scholar 

  21. NeveJ. and CarpentierY.A. (1988): Laboratory methods for assessment of selenium status, In: Nutrition in clinical practice, ed. by Hartig Dietze, Berlin, Weiner Furst, pp. 273–286.

    Google Scholar 

  22. PrasadA.S., RabbaniP., AbbasiiA., BowersoxE. and FoxM.R. (1978): Experimental zinc deficiency in humans - Ann. Intern. Med. 89: 483–490.

    Google Scholar 

  23. RotruckJ.T., PopeA.L., GantherH.E., SwansonA.B., HafemanD. and HoekstraW.G. (1973): Selenium: biochemical role as a component of glutathione peroxidase - Science 179: 588–590.

    Google Scholar 

  24. RusselG.R., NaderC.J. and PatrickE.J. (1980): Induction of DNA repair by some selenium compounds - Cancer Lett. 10: 75–81.

    Google Scholar 

  25. SAS (1990): User's Guide, Statistics, Version 7ed. Cary, N.C., SAS Institute, Inc.

    Google Scholar 

  26. SchwarzK. (1976): Essentially and metabolic functions of selenium - Med. Clin. North. Am. 60: 745–758.

    Google Scholar 

  27. Smith VanderkooyP.D. and GibsonR.S. (1987): Food consumption patterns of Canadian preschool children in relation to zinc and growth status - Am. J. Clin. Nutr. 45: 609–616.

    Google Scholar 

  28. SolbergH.E. (1981): Statistical treatment of collected reference values and determination of reference limits. In: Reference values in laboratory medicine, ed. by Grasbeck R. and Alstrom T., New York, John Wiley & Sons, pp. 193–205.

    Google Scholar 

  29. SolomonsN.W. (1979): On the assessment of zinc and copper nutriture in man - Am. J. Clin. Nutr. 32: 856–871.

    Google Scholar 

  30. StadtmanT.C. (1980): Selenium-dependant enzymes- Ann. Rev. Biochem. 49: 93–110.

    Google Scholar 

  31. TestolinG., CiapellanoS., LanzoleE. and AllegriniM. (1987): Effects of various dietary selenium intake on the blood glutathione peroxidase and selenium in long-term fed rats - Ann. Nutr. Metab. 31: 304–311.

    Google Scholar 

  32. ThomsonC.D. and RobinsonM.F. (1980): Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand - Am. J. Clin. Nutr. 33: 303–323.

    Google Scholar 

  33. ValentineJ.L., KangH.K. and SchluchterM. (1980): Selenium concentrations and glutathione peroxidase activities in a population exposed to selenium via drinking water - J. Toxicol. Environ. Health, 6: 731–736.

    Google Scholar 

  34. VanCaillie-BertrandM., DegenhartH.J. and FernandesJ. (1986): Influence of age on the selenium status in Belgium and the Netherlands -Ped. Res. 20: 574–576.

    Google Scholar 

  35. VanRijA.M., ThomsonC.D., McKenzieJ.M. and RobinsonM.F. (1979): Selenium deficiency in total parenteral nutrition - Am. J. Clin. Nutr. 32: 2076–2083.

    Google Scholar 

  36. VersieckJ. and CornelisR. (1980): Normal levels of trace elements in human blood plasma or serum -Anal. Chim. Acta 116: 217–254.

    Google Scholar 

  37. WallworkJ.C. (1987): Appraisal of the methodology and applications for measurements of the zinc content of blood components as indicators of zinc status - Biol. Trace Elem. Res. 12: 335–350.

    Google Scholar 

  38. WestermackT., RaunuP., KirjarintaM. and LappalainenL. (1977): Selenium content of whole blood and serum in adults and children of different ages from different parts of Finland - Acta Pharmacol. Toxicol. 40: 465–475.

    Google Scholar 

  39. WhitehouseR.C., PrasadA.S., RabbaniP. and CossakZ.T. (1982): Zinc in plasma, neutrophils, lymphocytes and erythrocytes as determined by flameless atomic absorption spectrometry - Clin. Chem. 19: 475–480.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malvy, D.JM., Arnaud, J., Burtschy, B. et al. Reference values for serum zinc and selenium of French healthy children. Eur J Epidemiol 9, 155–161 (1993). https://doi.org/10.1007/BF00158785

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00158785

Key words

Navigation