Abstract
Clustering of cases of dermatophytosis suggests that inherited susceptibility may play a part in determining the epidemiology of some forms of this infection, notably tinea imbricata. Some studies of T. concentricum infection show that autosomal recessive susceptibility may provide an answer although this is not the case in all endemic areas. Further support comes from the association between dermatophytosis in man and inherited conditions such as atopy, chronic mucocutaneous candidosis and tylosis as well as experimental data showing that susceptibility to dermatophytosis in mice varies in different inbred strains. Possible mechanisms are discussed.
Similar content being viewed by others
References
AhonenP., MyllarniemiS., SipilaIet al. (1990): Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients - New Eng. J. Med. 322: 1829–1836.
AjelloL. (1960): Geographic distribution and prevalence of dermatophytes - Annal of the New York Academy of Science 89: 30–38.
CalderonR.A. and HayR.J. (1984): Cell-mediated immunity in experimental murine dermatophytosis. I: T-suppressor activity elicited in dermatophyte infections caused by T. quinckeanum. Immunology 53: 457–464.
CastellaniA. and ChalmersA.J. (1919): Tinea imbricata (Tokelau). In Manual of Tropical Medicine- London: Balliere, Tindal and Cox. pp. 2059–2072.
ElmrosT. and LidenS. (1983): Hereditary palmoplantar keratoderma; incidence of dermatophyte infections and the results of topical treatment with retinoic acid - Acta. Dermatovener. 63: 254–257.
EnglishM.P. (1959): Trichophyton rubrum infection in families - Br. Med. J. i: 744–746.
daFonsecaO. (1972): The endodermophycae; tinea imbricata (Tokelau-Chimbere) Essays on Tropical Dematology - March J. (ed). Amsterdam: Excepta Medica. pp. 339–355.
HanifinJ.M., RayL.F. and LobitzW.C. (1974): Immunological reactivity in dermatophytosis - Br. J. Dermatol. 90: 1–5.
HayR.J., ReidS., TalwatE. and MacnamaraK. (1983): Immune responses of patients with tinea imbricata -Br. J. Dermatol. 108: 581–586.
HayR.J., ReidS., TalwatE. and MacnamaraK. (1984): Endemic tinea imbricata - a study on Goodenough island, Papua New Guinea - Trans. Roy. Soc. Trop. Med. Hyg. 78: 246–251.
HayR.J. and ShennanG.I. (1984): Antibody responses in tinea imbricata. The role of immunoglobulin E - Trans. Roy. Soc. Trop. Med. 78: 653–655.
HayR.J. (1987): Tinea imbricata. In current Topics in Medical Mycology. Springer Verlag - N. York 2: 55–72.
JonesH.E., ReinhardtJ.H. and RinaldiM. G. (1974): Immunologic susceptiblity to chronic dermatophytosis - Archs. Dermatol. 110: 213–218.
LiautaudB. and MarillF.G. (1984): La maladie dermatophytique. Observations Algeriennes recentes -Bull. Soc. Fr. Pathol. Exotique 77: 637–648.
MaclennanR. (1972): The trichophytin test in tinea imbricata. Papua New Guinea - Med. J. 15: 201–214.
MaclennanR. and O'KeefeM. (1975): Attitute and prevalence of tinea imbricata in New Guinea - Trans. Roy. Soc. Trop. Med. Hyg. 69: 91–93.
MansonP. (1978): Notes on tinea imbricata, an undescribed species of body ringworm - Medical Reports (China) 16: 1–11.
PoluninI. (1952): Tinea imbricata in Malaya - Br. J. Dermatol. 64: 378–384.
RavineD., TurnerK.J. and AlpersM.P. (1980): Genetic inheritance of susceptibility to tinea imbricata - J. Med. Genet. 17: 342–348.
SamsW.M., JorizzoJ.L., SnydermanR.et al. (1979): Chronic mucocutaneous candidiasis; immunological studies of three generations of a single family - Am. J. Med. 67: 948–959.
SerjeantsonS.and LawrenceG. (1977): Autosomal recessive inheritance of susceptibility of tinea imbricata - Lancet i: 13–15.
SmithC.A.B. (1956): A test for segregation ratios in family data - Annas. Hum. Genet. 20: 257–264.
SvejgaardE., JakobsenB. and SvejgaardA. (1983): HLA studies in chronic dermatophytosis caused by Trichophyton rubrum - Acta. Dermatovener. 62: 289–293.
WellsR.S., HiggsJ.M., MacDonaldD.et al. (1972): Familial chronic mucocutaneous candidiasis - J. Med. Genet. 9: 642–643.
Young M. W. (1971): Fighting with Food. Leadership values and Social Control in a Massim Society -Cambridge University Press. pp. 1–18.
ZuritaJ. and HayR.J. (1987): The adherence of dermatophyte microconidia and arthroconidia to human keratinocytes in vitro - J. Invest. Dermatol. 89: 529–534.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hay, R.J. Genetic susceptibility to dermatophytosis. Eur J Epidemiol 8, 346–349 (1992). https://doi.org/10.1007/BF00158566
Issue Date:
DOI: https://doi.org/10.1007/BF00158566