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Aciclovir and Trifluorothymidine in herpetic keratitis preliminary report of a multicentered trial

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Abstract

The efficacy of Aciclovir and Trifluorothymidine (TFT) treatment was tested in a double blind trial of thirty-eight patients with dendritic keratitis. All twenty patients treated with Aciclovir healed within 10 days with an average healing time of 5.0 days. Two of the eighteen patients treated with TFT failed to heal within 22 days, the others healed within ten days, the average healing was 6.6 days. Punctate keratopathy was seen in 70% of both groups. Intense conjunctival hyperaemia developed in two TFT patients.

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References

  • Bauer, D.J., Collins, P., Tucker, Jr., W.E. & Macklin, A.W. Treatment of experimental herpes simplex keratitis with acycloguanosine. Brit. J. Ophthal. 63: 429–435 (1979).

    Google Scholar 

  • Collins, P. & Bauer, D.J. The activity in vitro against herpes simplex of 9-(2-hydroxyethoxymethyl) guanine. J. Antimicrobial Chemotherapy 5: 431 (1979).

    Google Scholar 

  • Coster, D.J., Jones, B.R. & McGill, J.I. Treatment of amoeboid herpetic ulcers with adenine arabinoside or trifluorothymidine. Brit. J. Ophthal. 63: 418–421 (1979).

    Google Scholar 

  • Hyndiuk, R.A., Charlin, R.E., Alpren, Th.V.P. & Schultz, R.O. Trifluridine in resistant human herpetic keratitis. Arch. Ophthal. 96: 1839–1841 (1978).

    Google Scholar 

  • Jones, B.R., Coster, D.J., Fison's, P.N., Thompson, G.M., Coles, L.M. & Falcon, M.G. Efficacy of acycloguanosine against herpes simplex corneal ulcers. Lancet 1/8110: 243–244 (1919).

    Google Scholar 

  • Kaufman, H.E. Antiviral update. Ophthalmology 86: 131–136 (1979).

    Google Scholar 

  • Oosterhuis, J.A., Nolen, W.A., Sie, S.H. & Versteeg, J. Poly I.: C. in herpetic keratitis in rabbits. Exp. Eye Res. 18: 371–380 (1974).

    Google Scholar 

  • Oosterhuis, J.A., Versteeg, J., Kruit, P.J. & Postma, B.H. Aciclovir treatment in experimental herpetic keratitis in rabbits. Ophthal. Res. 12: 38–44 (1980).

    Google Scholar 

  • Pavan-Langston, D., Campbell, R.E. & Lass, J. Acyclic antimetabolite therapy of experimental herpes simplex keratitis. Amer. J. Ophthal. 86: 618–623 (1978).

    Google Scholar 

  • Wellings, P.C., Awdry, P.N., Bors, F.H., Jones, B.R., Brown, D.C. & Kaufman, H.E. Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers. Amer. J. Ophthal. 73: 932–942 (1972).

    Google Scholar 

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  1. C. La Lau

    Present address: Ophthalmological Department, Academic Hospital Leiden, Rijnsburgerweg 10, 2333, AA Leiden, The Netherlands

Authors and Affiliations

  1. Leiden/Rotterdam/The Hague/Maastricht, The Netherlands

    C. La Lau, J. A. Oosterhuis, J. Versteeg, G. Van Rij, J. G. C. Renardel De Lavalette, A. Craandijk, W. R. M. J. Lamers & Th. Mierlobensteyn

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  1. C. La Lau
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  2. J. A. Oosterhuis
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  3. J. Versteeg
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  4. G. Van Rij
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  5. J. G. C. Renardel De Lavalette
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  6. A. Craandijk
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  7. W. R. M. J. Lamers
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  8. Th. Mierlobensteyn
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La Lau, C., Oosterhuis, J.A., Versteeg, J. et al. Aciclovir and Trifluorothymidine in herpetic keratitis preliminary report of a multicentered trial. Doc Ophthalmol 50, 287–290 (1981). https://doi.org/10.1007/BF00158011

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  • DOI: https://doi.org/10.1007/BF00158011

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