Abstract
Immune responses to trivalent inactivated whole virus and monovalent subunit influenza vaccines, used in the season 1986–87, were analyzed in elderly residents in nursing homes. Higher levels of induced antibody were found in the group receiving two doses of trivalent vaccine. This suggests that high risk aged patients should receive a booster dose of vaccine annually. The antibody response to administration of supplemental vaccination, using monovalent subunit preparation, did not reach the high level of antibodies found following trivalent influenza vaccine.
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References
Alling D.W., Blackwelder W.C. and Stuart-Harris C.H. (1981): A study of excess mortality during influenza epidemics in U.S. 1968–1976. - Am. J. Epidemiol. 113: 30–43.
Arden N.H., Patriarca P.A. and Kendal A.P. (1986): Experiences in the use and efficacy of inactivated influenza vaccine in nursing homes. Options for the Control of Influenza. Alan R. Liss, Inc. 155-68.
Armitage P. (1974): Statistical methods in medical research. N.Y. Halsed press J. Wiley.
Barker W.H. and Mullooly Y.P. (1980): Influenza vaccination of elderly persons. Reduction in pneumonia and influenza hospitalizations and deaths. - J.A.M.A., V. 244, N. 22, 2547–2549.
Fox J.P.,Elveback L., Scott W. and Gatewood L. (1971): Herd immunity. Basic concept and relevance to pubblic health immunization practices. - Am. J. Epidemiol. 94: 179–89.
Glezen W.P., Payne A.A., Snyder D.N. and Downs T.D. (1982): Mortality and influenza. - J. Inf. Dis. 146: 313–321.
Mc Glone F.B. and Arden N.H. (1987): Impact of influenza in geriatrics and an action plan for prevention and treatment. - The Am. J. Medicine V. 82 (6A): 55–57.
Mc Kenzie J.S. (1977): Influenza subunit vaccine: antibody responses to one and two doses of vaccine and length of response, with particular reference to the elderly. - Br. Med. J. 1: 200–202.
Mancini G., Donatelli I., Arangio-Ruiz G., Rozera C. and Macchia T. (1983): Comparison of haemagglutination inhibition and single radial haemolysis techniques for detecting antibodies to influenza A and B viruses. - J. Hyg. Camb 91:157–162.
Patriarca P.A., Weber J.A., Parker R.A., Hall W.N., Kendal A.P., Bregman D.J. and Schonberger L.B. (1985): Efficacy of influenza vaccine in nursing homes. - J.A.M.A., V. 235, N. 8, 1136–1139.
Ruben F.L. (1986): Who needs influenza vaccine? Options for the control of influenza. - Alan R. Liss, Inc. 139–154.
Schild G.C., Pereira M.S. and Chakraverty P. (1975): Single Radial Haemolysis; a new method for assay of antibodies to influenza haemagglutination. - Bull. W.H.O 52: 43–50.
Weekly Epidem Rec. (1986): 61: 61–64, 237–238.0796 1062 V
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Mancini, G., Arangio-Ruiz, G., Bianchi, B. et al. Influenza vaccination in elderly residents in nursing homes: Immune response to trivalent and monovalent inactivated influenza virus vaccine in the season 1986–87. Eur J Epidemiol 5, 214–218 (1989). https://doi.org/10.1007/BF00156833
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DOI: https://doi.org/10.1007/BF00156833