Summary
Streptomyces cattleya and Streptomyces clavuligerus were found to form immobilized populations on cotton cloth. The resulting bacterial films were used as resident inocula in batch fermentations of thienamycin and cephalosporin C. During 20 cycles of 3-day batch fermentation, these antibiotics were produced at the constant yields.
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Joshi, S., Yamazaki, H. Repeated batch antibiotic fermentation by streptomycetes immobilized on cotton cloth. Biotechnol Tech 1, 45–48 (1987). https://doi.org/10.1007/BF00156286
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DOI: https://doi.org/10.1007/BF00156286