Abstract
The phenotypic effects of different doses of the dominant, sex-linked mutant Notch (N) and its wildtype allele (N +) were studied in Drosophila hydei, N being lethal in homozygous or hemizygous condition. Various dosage combinations were made by using N + N and N + N + attached-X chromosomes as well as X and Y N +-duplication chromosomes (w mCoY, XwmCo,and DpCo Nt). The N mutant used, N 68, is associated with a small inversion: In (I) N 68.
The wing phenotype was found to depend solely on the number of functional (N +) alleles present, irrespective of the dose of N. Females with a single dose of N + are phenotypically Notch, females with three or four doses of N + show a Confluens wing phenotype. The latter occurs in varying degrees of expression which seem to be correlated with the relative amounts of sex-chromosomal heterochromatin present. In males the N + locus behaves as a dosage compensated locus either on the X or the Y chromosome.
In the w mCo (w+N+) duplication, the w + locus shows variegation when placed over white, whereas N + placed over N 68 does not. The former being situated closer to the heterochromatin in this aberration, this is consistent with the idea of gene inhibition by heterochromatin but at the same time would imply a very limited spreading effect.
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van Breugel, F.M.A. The action of the Notch locus in Drosophila hydei . Genetica 42, 25–41 (1971). https://doi.org/10.1007/BF00154837
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DOI: https://doi.org/10.1007/BF00154837