Abstract
Mutants of Salmonella typhimurium, which contain different quantities of outer membrane proteins, show different susceptibility to phagocytosis. We correlate susceptibility to phagocytosis with molecular surface characteristics which are responsible for invasiveness and virulence of bacteria.
Similar content being viewed by others
References
Di DonatoA., DraettaG.F., IllianoG., TufanoM.A., SommeseL. and GaldieroF. (1986): Do porins inhibit the macrophage phagocyting activity. - J. Cycl. Nucleot. Prot. Phosphoryl. Res. 11 (2), 87–97.
GalanosC., LuderityO. and WestphalO. (1969): A new method for the extraction of R lipopolysaccharides. -Eur. J. Biochem. 9, 245–249.
GaldieroF., TufanoM.A., RossiF., FilippelliW., DelGaudioF., BerrinoL. and MarmoE. (1987): Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus. - J. Med. 17 (5/6), 285–298.
GaldieroF., TufanoM.A., SommeseL., FolgoreA. and TedescoF. (1984): Activation of complement system by porins extracted from Salmonella typhimurium. -Infect. Immun. 46, 559–563.
HildebrandtJ.F., MayerL.W., WangS.P. and BuchmanT.M. (1978): Neisseria gonorrhoeae acquire a new principal outer-membrane protein when transformed to resistance to serum bactericidal activity. - Infect. Immun. 20, 267–273.
KuusiN., NurminenM., SaxenH., ValtonenM. and MakelaP.H. (1979): Immunization with major outer membrane proteins in experimental salmonellosis of mice. - Infect. Immun. 25, 857–862.
LaemmliU.K. (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. - Nature (London) 227, 680–685.
LowryO.H., RosebroughN.J., FarrA.L. and RandallR.J. (1951): Protein measurement with Folinphenol reagent. - J. Biol. Chem. 193, 265–275.
Mc BrideH.M., LamberdenP.R., HeckelsJ.E. and WattP.J. (1981): The role of outer membrane proteins in the survival of Neisseria gonorrhoeae P9 within guinea p?g subcutaneous chamber. - J. Gen. Microbiol. 126, 63–67.
MunnC.B., IshiguroE.E., KayW.N. and TrustT.J. (1982): Role of surface components in serum resistance of virulent Aeromonas salmocida. - Infect. Immun. 36, 1069–1075.
NurminenM., LounatmaaK., SarvasM., MakelaP.H. and NakaeT. (1976): Bacteriophage-resistant mutants of Salmonella typhimurium deficient in two major outer membrane proteins. - J. Bacteriol. 127, 941–955.
OsbornJ., GanderJ.E., ParisiE. and CarsonJ. (1972): Mechanism of assembly of the outer membrane of Salmonella typhimurium. - J. Biol. Chem. 247, 3962–3972.
ParsonN.J., KwaasiA.A.A., PereraV.Y., PatelP.V., MartireP.M.V. and SmithH. (1982): Outer membrane proteins of Neisseria gonorrhoeae associated with survival within human polymorphonuclear phagocytes. - J. Gen. Microbiol. 128, 3077–3081.
RosenbergM., GutmickD. and RosenbergE. (1980): Adherence of bacteria to hydrocarbons: a simple method for measuring cell-surface hydrophobicity. -FEMS Microbiol. Lett. 9, 29–33.
TaylorP.W. and PartonR. (1977): A protein factor associated with serum resistance in Escherichia coli. -J. Med. Microbiol. 10, 225–232.
TylewkaS.K., HjertenS. and WadstromT. (1979): Contribution of M protein to the hydrophobic surface properties of Streptococcus pyogenes. -FEMS Microbiol. Lett. 6, 249–253.
TsaiC.M. and FrashC.E. (1982): A sensitive silver stain for detecting lipopolysaccharide in polyacrilamide gels. - Anal. Biochem. 119, 115–119.
TufanoM.A., BerlingieriM.T., SommeseL. and GaldieroF. (1984): Immune response in mice and effects on cells by outer membrane porins from Salmonella typhimurium. - Microbiologica, 7, 353–366.
Tufano M.A., Rossano R. and Galdiero F. (1982): Effect of porins from Salmonella typhimurium on the mouse: immunomodulation and some functional systemic modifications. FEMS Symposium on bacterial and viral inhibition and modulation of host defences. - Pisa, September.
TufanoM.A., SommeseL., CapassoC., FolgoreA., ScafaF. and GaldieroF. (1986): Comparative study of some biological activities of porins extracted from various microorganisms. - Microbiologica 9, 431–442.
VaccaC., LucarelliL., TufanoM.A., GaldieroF. and MarmoE. (1984): Effetti delle porine di Salmonella typhimurium sull'aggregazione di piastrine umane. - Eur. Rev. Med. Pharmacol. Sci. VI, 597–602.
VanOssC.J. (1978): Phagocytosis as a surface phenomenon. - Annal. Rev. Microbiol. 32, 19–39.
VanZwetT.L., ThompsonJ. and VanFurthR. (1975): Effect of glucocortisteroids on the phagocytosis and intracellular killing by peritoneal macrophages. - Infect. Immun. 12, 699–705.
WilkinsonR.G., GemskiP.Jr. and StockerB.A.D. (1972): Non smooth mutants of Salmonella typhimurium: differentiation by phage sensitivity and genetic mapping. - J. Gen. Microbiol. 70, 527–554.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tufano, M.A., Sommese, L., Capasso, C. et al. Porin content modifies resistance of Salmonella typhimurium to phagocytosis. Eur J Epidemiol 4, 110–114 (1988). https://doi.org/10.1007/BF00152701
Issue Date:
DOI: https://doi.org/10.1007/BF00152701