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Enantioselective inhibition studies of the cyclohexanone monooxygenase from Acinetobacter sp. NCIMB 9871

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Summary

Cyclohexanone monooxygenase from Acinetobacter sp. NCIMB 9871 can be inhibited by bicyclic thiolactones. No evidence was obtained for enantioselective inhibition of the enzyme using this class of inhibitors in enantiomerically enriched form. This evidence supports the supposition that there is a single active site for this enzyme.

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Authors and Affiliations

  1. Research School of the Biosciences, University of Kent at Canterbury, CT2 7NJ, Canterbury, Kent, UK

    Michael Wright & Christopher Knowles

  2. Groupe de Chimie Organique et Bioorganique, URA CNRS 1320, Faculté des Sciences de Luminy, Université d'Aix-Marseille II, Case 901, 163 Avenue de Luminy, 9, Marseille Cedex, France

    Frédéric Petit & Roland Furstoss

Authors
  1. Michael Wright
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  2. Christopher Knowles
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  3. Frédéric Petit
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  4. Roland Furstoss
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Wright, M., Knowles, C., Petit, F. et al. Enantioselective inhibition studies of the cyclohexanone monooxygenase from Acinetobacter sp. NCIMB 9871. Biotechnol Lett 16, 1287–1292 (1994). https://doi.org/10.1007/BF00149633

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  • DOI: https://doi.org/10.1007/BF00149633

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