Summary
The efficacy of a fixed combination of 10 mg nifedipine and 100 mg acebutolol was tested in 21 patients with angiographically proven coronary artery disease (CAD). Ejection fraction (EF), emptying and filling rate (VS and VD), and end-systolic volume (ESV) were assessed by means of radionuclide ventriculography at rest and during exercise prior to as well as 1 hour and 5 hours following oral drug application. Whereas exercise-induced worsening of cardiac function had been documented in all the patients prior to medication, EF and ESV improved significantly after drug administration.
Similar content being viewed by others
References
Aellig WH. Clinical pharmacology of pindolol. Am Heart J 1982;104:346–357.
Bauer R, Sauer E, Truckenbrodt R, et al. Die linksventrikuläre Herzfunktion in Ruhe und unter Ergometerbelastung. Herz 1980;5:159–167.
Bauer R, Kiefl S, Lutilsky L, et al. Wirkung von Nifedipin bei Koronarer Herzkrankheit (KHK). Nukl Med Suppl 1984; 21:274–277.
Bauer R, Busch U, Klein G, et al. Nifedipine als 2-Phasentablette bei Patienten mit Koronarer Herzkrankheit. Herz/Kreisl 1987;19:370–378.
Becker H-J, Kaltenbach M, Werner H, et al. Dosiswirkungsrelation von Kalzium-antagonisten und Isosorbiddinitrat bei Patienten mit stabiler Angina pectoris. In: FleckensteinA, RoskammH, eds. Calcium-antagonismus Berlin: Springer-Verlag, 1980:318.
Bertrand ME, Lablanche JM, Tilmant PY. Treatment of spasm of the coronary artery with nifedipine. Eur Heart J 1980;1(Suppl B): 65–69.
Fleckenstein A. Calcium antagonism in heart and smooth muscle. Experimental facts and therapeutic prospects. New York: John Wiley & Sons, 1983.
Meier J. Pharmacokinetic comparison of pindolol with other beta adrenoceptor blocking agents. Am Heart J 1982;104: 364–373.
Pfisterer M, Müller-Rnadt J, Burkart F. Combined acebutolol/nifedipine therapy in patients with chronic coronary artery disease: Additional improvement of ischemia-induced left ventricular dysfunction. Am J Cardiol 1982;49:1259–1266.
Simon R. Kalziumantagonisten: Wirkung auf periphere and koronare Hämodynamik. Z Kardiol 1984;73(Suppl 2):79–88.
Strasser R, Klepzig H. Wirkung von Nifedipine und Acebutolol einzeln und in Kombination bei Patienten mit Angina pectoris. In: JustHJ, ed. Erfahrungen mit Adalat in Klinik und Praxis. Erlangen: Perimed Verlag 1983:61–68.
Theroux P, Taeymans Y, Waters DD. Calcium antagonists. Clinical use in the treatment of angina. Drugs 1983;25:178–195.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bauer, R., Busch, U., Lutilsky, L. et al. The efficacy of nifedipine and acebutolol in coronary artery disease assessed by radionuclide ventriculography. Cardiovasc Drug Ther 3 (Suppl 1), 287–293 (1989). https://doi.org/10.1007/BF00148473
Issue Date:
DOI: https://doi.org/10.1007/BF00148473