Abstract
Five hundred and fifty samples of blood collected from the umbilical cords of an equivalent number of newborns were analized for serological evidence of congenital toxoplasmosis based on the detection of IgG and IgM. Six newborns presented serological evidence of congenital toxoplasmosis (IgM > 1:5, < 80 IU/ml), which represents an incidence of 10.9 per 1000 live births. During pregnancy four of the mothers of these six newborns were asymptomatic, whereas the other two mothers presented non-specific signs and symptoms. The six newborns did not present positive signs of acute toxoplasmosis at birth. Three false positive were identified, all secondary to the presence of a rheumatoid (RF) and/or antinuclear factor (ANF). And in one of them the diagnosis of congenital syphilis was confirmed. The percentage of women that tested serum positive for IgG antibodies increased with age, with 55.8% of the pregnant women testing serum-negative, therefore carrying the risk of acquired toxoplasmosis in future pregnancies.
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References
Aguilar F.C. (1960): Consideraciones sobre toxoplasmosis en Guatemala. Guatemala, Thesis, Guatemala City: San Carlos University.
Alfond C.A. (1969): Subclinical central nervous system diseases of neonates: a prospective study of infants born with increased levels of IgM - J. Pediatr. 75: 1167.
Alfond C.A. and Pass R.F. (1981): Epidemiology of chronic congenital and perinatal infections of man -Clin. Perinatol. 8: 397–414.
Bolognise R.J., Aldinger R. and Roberts N. (1981): Prenatal care in the prevention of infection - Clin. Perinatol 8: 605–616.
Byrn F. W. and Gibson M. (1986): Infectious causes of recurrent pregnancy loss - Obstet and Gynecol. Clin. North Am. 29: 925–940.
Cacciapuoti B., Ciceroni L. and Lanetti P. (1981): Antitoxoplasma antibodies in mothers in labor and their newborn children - Boll. Ist. Sieroter. Milan 60: 121–128.
Castillejos J.A. (1984): Determinacion de anticuerpos contra Toxoplasma gondii, estudio efectuado en 100 niñas de 12 a 18 años en una escuela urbana de la capital. Thesis Guatemala City: San Carlos Univesity.
Daniel W. W., Bioestadistica: Base para el analisis de las ciencias de la salud. Ed. LIMUSA 3a. Ed. 202.
Feldman H.A. (1969): Toxoplasma and toxoplasmosi -Hosp. Pract. 4: 64.
Foulon W., Neaessens A., Volckaert M. et al. (1984): Congenital Toxoplasmosis: a retrospective survey in Brussels - Br. J. Obstet. Gynaecol 91: 419–423.
Frenkel J.K. (1985): Toxoplasmosis - Pediat. Clin. North Am. 32: 917–932.
Gonzales M. G. (1982): Investigacion de toxoplasmosis en embarazadas que consultan al Puesto de Salud de Flores, Costa Cuca, Quetzaltenango, del 15/8/81 al 15/1/82. Thesis Guatemala City: San Carlos University.
Hegst P. (1982): The effectiveness of general test for Toxoplasma gondii infection in pregnancy- Zentralb Gynakol 104: 949–956.
Hoekenga M.T. (1956): Toxoplasmosis en Honduras -Rev. Med. Honduras 23: 1160–1165.
Hyde R., Barnett E.V. and Remington J.S. (1975): Method for differentiation of non-specific from specific toxoplasma IgM fluorescent antibodies in patients with rheumatoid factor - Proc. Soc. Exp. Biol. Med. 148: 1184–1188.
Langer H. (1963): Repeated congenital infection with Toxoplasma gondii - Obstet. Gynecol. 21: 318.
Loke Y.W. (1982): Transmission of parasites across the placenta - Adv. Parasitol. 21: 155–228.
Maguire J.H. (1986): Toxoplasmosis. In: Parsonnet J. ed. Infectious Diseases - Boston: Harvard Medical School 1: 1–7.
Mahmoud A.F. and Waqrren K.S. (1977): Algorithms in the diagnosis and management of exotic diseases. Toxoplasmosis - J. Infect. Dis. 135: 493–496.
McLeod R. and Remington J.S. (1980): Toxoplasmosis. In: Isselbacher K.J., Adams R.D., Brawnwald E., et al. (eds.). Harrison's Principles of Internal Medicine -U.S.A.: McGraw Hill Book Co 879–885.
Naot Y., Barnett E.V. and Remington J.S. (1981): Method for avoiding false-positive results ocurring in immunoglobulin M enzyme-linked immunosorbent assays due to the presence of both rheumatoid factor and antinuclear antibodies - J. Clin. Microbiol. 142: 73–78.
Panush R. (1979): Autoantibodies and human disease. In: Waldman R.H., ed. Clinical concepts of Immunology - Baltimore: The William and Wilkins Company 146–150.
Remington J.S., Miller M.J. and Browlee M.S. (1968): IgM antibodies in acute toxoplasmosis: Diagnostic significance in congenital cases and a method for their rapid demonstration - Pediatrics 41: 1082–1091.
Roux Ch., Gaulier M., Mulliez N. et al., (1976): Diagnosis and prophylaxes of congenital toxoplasmosis - J. Gynecol. Obstet. 5: 249–264.
Schwarcz R., Sala S. and Duverges C. (1975): Toxoplasmosis. In: Schwarcz R., Sala S., Duverges C., (eds.) - Obstetricia. Buenos Aires: El Ateneo 401–403.
Stevenson R.E. (1977): Influences of the perinatal environment. In: Stevenson R.E. (ed.). The Fetus and Newly Born Infant. St. Lous: C.V. Mosby Co. 319–333.
Storms D. and Quinley J. (1988): A field guide for adding vitamin A interventions to PVO Child survival projects. Report of a special PVO child survival task force on vitamin A - Baltimore Maryland.
Stray-Pedersen B. and Lorentzen-Styr A.M. (1979): The prevalence of toxoplasma antibodies among 11,736 pregnant women in Norway - Scand. J. Infect. Dis. 11: 159–165.
Van derVeen and Polak M.F. (1980): Prevalence of toxoplasma antibodies according to age with comment on the risk of prenatal infection - J. Hyg. (Lond) 85: 165–174.
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Sinibaldi, J., De Ramirez, I. Incidence of congenital toxoplasmosis in live Guatemalan newborns. Eur J Epidemiol 8, 516–520 (1992). https://doi.org/10.1007/BF00146369
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DOI: https://doi.org/10.1007/BF00146369