Skip to main content
Log in

Unexpected effects of coffee consumption on liver enzymes

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript


The effects of regular daily coffee consumption on liver enzymes were studied in a large number of subjects from the general population. In coffee drinkers, liver enzymes (gamma-glutamyl transferase, alkaine-amino transferase, and alkaline phosphatase) and serum bilirubin were lower than in non-coffee-drinking subjects or in those consuming less than 3 cups daily. The hypothesis proposed is that liver enzymes are a target for caffeine contained in coffee.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. CasigliaE., MorminoP., SpolaoreP., CernettiC., CostaF. and AmbrosioG.B. (1990): Cardiovascular effects of coffee consumption in the elderly: the CASTEL study - Cardiologia 35: 827–832.

    Google Scholar 

  2. CasigliaE., SpolaoreP., MorminoP., Maschio0., ColangeliG., CelegonL., MaggioloG., TittotoL., PasinatoA. and AmbrosioG.B. (1991): The CASTEL project (Cardiovascular Study in Elderly: protocol, study design, and preliminary results of the initial survey - Cardiologia 36: 569–576.

    Google Scholar 

  3. CasigliaE., PaleariC.D., PetuccoS., BongioviS., ColangeliG., BaccillieriM.S., PavanL. and PessinaA.C. (1992): Haemodynamic effects of coffee and purified caffeine in normal volunteers: a placebo-controlled clinical study - J. Human Hypertension 6: 95–99.

    Google Scholar 

  4. CuratoloP.W. and RobertsonD. (1983): The health consequences of caffeine - Ann. Intern. Med. 98: 641–653.

    Google Scholar 

  5. DuBoisD. and DuBoisF. (1916): A formula to estimate the approximative surface area if height and weight are known - Arch. Int. Med. 17: 863–871.

    Google Scholar 

  6. TeicholzL.E., KreulenT., HermanM.Y. and GorlinR. (1976): Problems in echocardiographic volume determinations: echocardiographic and angiographic correlations in the presence or absence of asynergy - Am. J. Cardiol. 37: 7–11.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Casiglia, E., Spolaore, P., Inocchio, G. et al. Unexpected effects of coffee consumption on liver enzymes. Eur J Epidemiol 9, 293–297 (1993).

Download citation

  • Issue Date:

  • DOI:

Key words