The effects of regular daily coffee consumption on liver enzymes were studied in a large number of subjects from the general population. In coffee drinkers, liver enzymes (gamma-glutamyl transferase, alkaine-amino transferase, and alkaline phosphatase) and serum bilirubin were lower than in non-coffee-drinking subjects or in those consuming less than 3 cups daily. The hypothesis proposed is that liver enzymes are a target for caffeine contained in coffee.
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Casiglia, E., Spolaore, P., Inocchio, G. et al. Unexpected effects of coffee consumption on liver enzymes. Eur J Epidemiol 9, 293–297 (1993). https://doi.org/10.1007/BF00146266