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Antibodies to HTLV-1–2, HIV-1 and HIV-2 in syphilitic patients

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Abstract

Antibodies to human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) and to human T-cell leukemia virus (HTLV-1) were investigated by ELISA, Western blot and radioimmunoprecipitation (RIPA) assay in 318 sera (191 males and 127 females) obtained from syphilitic patients. The sera from 10% of the males and 3.1% of the females were positive for HIV-1. None of the sera contained antibodies to HIV-2. Antibodies to HTLV-1–2 were present in the sera of 7.1% of the males and 4.8% of the females who were seronegative for HIV. Five out of 24 (20.8%) HIV-1 positive subjects had antibodies to HTLV-1–2 as well.

Sera from another group of 58 syphilitic patients (38 males and 20 females in the Anti-Venereal Disease Department), seronegative for HIV-1 and HIV-2, who denied both i.v. drug abuse and blood transfusion, were investigated in the same manner. None of the males had antibodies to HTLV-1–2, while 2 females (10%) were positive.

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Manca, N., Graifenberghi, S. & Colombrita, D. Antibodies to HTLV-1–2, HIV-1 and HIV-2 in syphilitic patients. Eur J Epidemiol 6, 201–206 (1990). https://doi.org/10.1007/BF00145794

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