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Community outbreak of acute respiratory infection by Mycoplasma pneumoniae

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Abstract

We present the results of the investigation of an epidemic outbreak of Mycoplasma pneumoniae infection which affected 95 school-children from certain villages in Catalonia. The investigation took an epidemiological, clinical and microbiological approach, detecting by capture enzyme-immunoassay technique the presence of IgM antibodies against M. pneumoniae. All cases occurred over a 9 week period. The attack rate in children under five was 18% and 8.2% in those from 5–14 years. The age mean and standard deviation of the cases was 5.2 ± 3.5 years, the range being from 9 months to 14 years. Cough was the most common clinical manifestation (87.4%), followed by fever (67.4%), asthenia (21.1%), abdominal pain (18.9%), vomiting (13.7%), earache (8.4%) and sore throat (6.3%). There was no significant difference in the distribution of symptoms according to age groups. IgM anti M. pneumoniae was positive in 36 (37.9%) of the samples analysed. Treatment chosen in most cases (90) was eritromicin and there was a correct evolution in all cases except for two clinical and radiological recurrences. Hospitalization was only necessary in 5 cases. The present findings are important to emphasize the high incidence of M. pneumoniae respiratory disease in children under 5, and suggests that with respiratory processes affecting very young children, a possible Mycoplasma pneumoniae infection should also be considered and the necessary action taken in the form of early and appropriate treatment.

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References

  1. Mamie TJ. Community-acquired pneumonia. Clin Inf Dis 1994; 18: 501–515.

    Google Scholar 

  2. Foy HMA. Mycoplasma pneumoniae. In: Evans A, ed Bacterial infections of humans, 2nd ed. New York: Plenum, 1991: 443–465.

    Google Scholar 

  3. Almirante B, Pahissa A, Planes AM, et al. Etiologia de las neumonias extrahospitalarias. Med Clin (Barc) 1985; 85: 175–178.

    Google Scholar 

  4. Benenson PS. Control of communicable diseases in man. Washington, DC: American Public Health Association, 1990: 332–334.

    Google Scholar 

  5. Couch RB. Mycoplasma pneumoniae (primary atypical pneumonia). In: Mandell G, Douglas RG, Bennett JE, eds, Principles and practice of infectious diseases, 3rd ed. New York: Churchill Livingstone, 1990:1446–1458.

    Google Scholar 

  6. Ghosh K, Clements GB. Surveillance of Mycoplasma pneumoniae infections in Scotland 1986–1991. J Infect 1992; 25: 221–227.

    Google Scholar 

  7. Kenny GE. Mycoplasmas. In: Balows A, Hausler WJ, Herrmann KL, Isenberg HD, Shadomy HJ, eds, Manual of clinical microbiology, 5th ed. Washington, DC: American Society for Microbiology, 1991: 478–487.

    Google Scholar 

  8. Samra Z, Gadba R. Diagnosis of Mycoplasma pneumoniae infection by specific IgM antibodies using a new capture-enzyme-immunoassay. Eur J Epidemiol 1992; 8: 824–826.

    Google Scholar 

  9. Khatib R, Schnarr D. Point-source outbreak of Mycoplasma pneumoniae infection in a family unit. J. Infect Dis 1985; 151: 186–187.

    Google Scholar 

  10. Monto AS. Acute respiratory infections 1992. In: Last JM, Wallace RB, eds, Public health and preventive medicine, 13th ed. Connecticut: Prentice-Hall, 1992: 125–130.

    Google Scholar 

  11. Clyde WA. Infecciones por Mycoplasmas. In: Wilson J, Braunwalde D, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK, et al. Principios de medicina interna, 12th ed. Madrid: Interamericana/McGraw Hill, 1991:

    Google Scholar 

  12. Sakurai N, Nagayama Y, Honda A, et al. Mycoplasma pneumoniae and other pathogens in the aetiology of lower respiratory tract infections among Japanese children. J Infect 1992; 16: 253–261.

    Google Scholar 

  13. Sillis M. Mycoplasma pneumoniae. Lancet 1991; 337: 1101.

    Google Scholar 

  14. Kleemola M, Heiskanen-Kosma T, Nohynek H, et al. Diagnostic efficacy of a Mycoplasma pneumoniae hybridization test in nasopharyngeal aspirates of children. Pediatr Infect Dis J 1993; 12: 344–347.

    Google Scholar 

  15. Nagayama Y, Sakurai N, Yamamoto K, et al. Isolation of Mycoplasma pneumoniae from children with lower-respiratory-tract infections. J Infect Dis 1988; 157: 911–917.

    Google Scholar 

  16. Sillis M, Harrison BDW. Clinical aspects of Mycoplasma pneumoniae infection. Lancet 1992; 339: 301–302.

    Google Scholar 

  17. Leibowitz Z, Schwartzman P, Epstein L, et al. An outbreak of Mycoplasma pneumoniae in two kibbutzim: a clinical and epidemiologic study. Isr J Med Sci 1988; 24: 88–92.

    Google Scholar 

  18. Kok TW, Marmion BP, Varkanis G, et al. Laboratory diagnosis of Mycoplasma pneumoniae infections. Detection of IgM antibodies to M. pneumoniae by a modified indirect haemagglutination test. Epidemiol Infect 1989; 103: 613–623.

    Google Scholar 

  19. Sillis M. The limitations of IgM assays in the serological diagnosis of M. pneumoniae infections. J Med Microbiol 1990;33: 253–258.

    Google Scholar 

  20. Vikerfors T, Brodin G, Grandien M, et al. Detection of specific IgM antibodies for the diagnosis of Mycoplasma pneumoniae infections: a clinical evaluation. Scand J Infect Dis 1988; 20: 601–610.

    Google Scholar 

  21. Taylor P, Gaya H. Comparison of a commercial μ capture ELISA with complement fixation and indirect agglutination for the serological detection of Mycoplasma pneumoniae infection. Serodiagnosis and Immunotherapy in Infectious Diseases 1990; 4: 225–261.

    Google Scholar 

  22. Skakni L, Sardet A, Just J, et al. Detection of Mycoplasma pneumoniae in clinical samples from pediatric patients by polymerase chain reaction. J Clin Microbiol 1992; 30: 2638–3643.

    Google Scholar 

  23. Marmion BP, Williamsm J, Worswick DA, et al. Experience with newer techniques for the laboratory detection of Mycoplasma pneumoniae infection: Adelaide 1978–1992. Clin Infect Dis 1993; 17 (suppl 1): 590–599.

    Google Scholar 

  24. Dular R, Lambert M, Bruce BW, et al. Mycoplasma pneumoniae infections in a rural setting in Canada. Can Med Assoc J 1987; 136: 1271–1273.

    Google Scholar 

  25. Uldum Sg Jensen JS, Sondergard-Andersen J, Lind K. Enzyme immunoassay for detection of Immunoglobulin M (IgM) and IgG antibodies to Mycoplasma pneumoniae. J Clinical Microbiol 1992; 30: 1198–1204.

    Google Scholar 

  26. Echevarria JM, Leon P, Balfagon P, et al. Diagnosis of Mycoplasma pneumoniae infection by microparticle agglutination and antibody-capture enzyme-immuno assay. Eur J Clin Microbiol Infect Dis 1990: 217–220.

  27. Mirza F, Ahmad AA, Ifere OA, Yakubu AM. Prevalence of Mycolasma pneumoniae in children with pneumonia in Zaria, Nigeria. Ann Trop Pediatr 1991; 11: 51–55.

    Google Scholar 

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Authors and Affiliations

  1. Department of Public Health and Health Regulations, University of Barcelona, Spain

    Angela Domínguez & Lluís Salleras

  2. Territorial Delegation of Health, Tarragona, Spain

    Sofia Minguell

  3. Centre of Primary Care Mora la Nova, Tarragona, Spain

    Joan Torres & Angelita Serrano

  4. Laboratory of Microbiology, Hospital Clinic, Barcelona, Spain

    Josep Vidal

Authors
  1. Angela Domínguez
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  2. Sofia Minguell
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  3. Joan Torres
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  4. Angelita Serrano
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  5. Josep Vidal
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  6. Lluís Salleras
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Domínguez, A., Minguell, S., Torres, J. et al. Community outbreak of acute respiratory infection by Mycoplasma pneumoniae . Eur J Epidemiol 12, 131–134 (1996). https://doi.org/10.1007/BF00145497

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