Abstract
Lipoprotein(a), or Lp(a), is a lipoprotein having lipid composition similar to that of LDL, but a protein moiety consisting of ApoB 100 linked by disulfide bridge to apo(a), a glycoprotein with structural similarity to plasminogen. Lp(a) can be both atherogenic and thrombogenic. These two actions are likely to be mutually operative, a fact that on a molar basis makes Lp(a) more of a cardiovascular pathogen than LDL.
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References
BergK. (1990): Lp(a) lipoprotein: An overview - In Lipoprotein(a) - A.M. Scanu - Ed. Academic Press -San Diego - CA 1–23.
BersotT.P.,InnerarityR.W.,PitasR.E.,RallS.C.,WeisgraberL.J. andMahleyR.W. (1986): Fat feeding in humans induces lipoproteins. of density less than 1,006 that are enriched in apolipoprotein(a) and that cause lipid accumulation in macrophages - J. Clin. Invest.77: 622–630.
BrewerH.B. (1990): Effectiveness of diet and drugs in the treatment of patients with elevated Lp(a) levels -In Lipoprotein(a) - A.M. Scanu - Ed. Academic Press San Diego - CA 211–220.
CushingG.L.,GaubatzJ.W.,NavaM.L.,BurdichB.J.,BocanT.M.A.,GuytonJ.R.,WeilbaecherD.,DeBakeyM.E.,LawrieG.M. andMorrisettJ.D. (1989): Quantitation and localization of apolipoprotein(a) and B in coronary artery bypass vein grafts resected at re-operation - Arteriosclerosis9: 593–603.
DahlenG.H. (1990): Incidence of Lp(a) among population - In Lipoprotein(a) - Scanu A.M. - Ed. Academic Press. Inc. San Diego - CA 151–172.
FlessG.M.,PfaffingerD.J.,EisanbartJ.D. andScanuA.M. (1990): Solubility immunochemical and lipoprotein binding properties of apoB100-apo(a) the protein moiety of lipoprotein(a) - J. Lip. Res.31: 909–918.
LoscalzoJ. (1990): Lipoprotein(a) — A unique risk factor for atherothrombotic disease - Arteriosclerosis10: 672–679.
McLeanJ.W.,TomlinsonJ.E.,KuangW.,EatonD.L.,ChenE.Y.,FlessG.M.,ScanuA.M. andLawnR.M. (1987): cDNA sequence of human apolipoprotein(a) is homologous to plasminogen - Nature330: 132–137.
RathM.S.,NiendorfA.,ReblinT.,DietelM.,KrebberJ.H. andBeisigelU. (1989): Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients - Arteriosclerosis9: 570–592.
ScanuA.M. (1990): Lipoprotein(a): A genetically determined cardiovascular pathogen in search of a function - J. Lab. Clin. Med.116: 142–146.
ScanuA.M. andFlessG.M. (1990): Lipoprotein(a) —Heterogeneity and Biological Relevance - J. Clin. Invest.85: 1709–1715.
TomlinsonJ.,McLeanJ. andLawnR. (1989): Rhesus monkey apolipoprotein(a) - J. Biol. Chem.264:5957–5965.
UtermannG. (1989): The mysteries of lipoprotein(a) -Science246: 904–910.
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Scanu, A.M. LP(A): A link between thrombosis and atherosclerosis. Eur J Epidemiol 8 (Suppl 1), 76–78 (1992). https://doi.org/10.1007/BF00145354
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DOI: https://doi.org/10.1007/BF00145354