Abstract
A screening study was performed on 106 children with familial risk for coronary heart disease (CHD) and on matched controls. The two groups differed in several parameters. Children of CHD patients exhibited significantly elevated levels of Lp(a) and total cholesterol, reduced HDL apo A1 and apo A2 and increased values of serum hexuronic acid. These results support the concept that genetic and familial factors contribute to the risk of atherosclerosis.
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BerensonB.G.,McMahanC.A. andVoorsA.W. (1980): Cardiovascular risk factors in children - New York -Oxford University Press: 453.
BergK. (1963): A new serum type system in man — the Lp system - Acta Pathol. Microbiol. Scand.59: 369–382.
BergK.,DahlenG. andPrickM.H. (1974): Lp(a) lipoprotein and pre - Clin. Genet.6: 230–235.
Bihari-Yarga M., Gruber E, Rothender F.M., Zoohnor R. andKostner G.M. (1988): Interaction of lipoprotein Lp(a) and low-density lipoprotein with glycosaminoglycans from human aorta -Arteriosclerosis 0.051–057.
BitterT. andMuirH. (1962): A modified uronic acid carbazole reaction - Analyt. Biochem.4: 330–335.
DahlenG.,EricsonC. andBergK. (1978):In vitro studies of the interaction of isolated Lp(a) lipoprotein and other lipoproteins with glycosaminoglycans -Clin. Genet.14: 36–42.
GhilainJ.M.,ParfonryA.,KozyroffV. andHollerF.R. (1988): Lipoprotein(a), cholesterol and coronary heart disease - The Lancet Oct.22: 963.
KemplerF.,KostnerG.M.,BolzanoK. andSandhoferF. (1980): Turnover of lipoprotein Lp(a) in man - J. Clin. Invest.65: 1483–1490.
KostnerG.M.,AvogaroP.,CazzolatoG.,MarthE.,Bittolo-BonG. andQuinciG.B. (1981): Lipoprotein Lp (a) and the risk for myocardial infarction -Atherosclerosis38: 51–61.
KostnerG.M. andBihari-YargaM. (1990): Is the atherogenicity of Lp(a) caused by its reactivity with proteoglycans? Europ. Heart J.11: 184–189.
MeletJ.,HooghwinkelG.J.,GiosbertsM.A. andVanGeldenH.H. (1980): A semi-quantitative micromethod for determination of glycosaminoglycans in serum — Results from studies on serum of healthy children of various age and patients affected by mucopolysaccharidosis - Clin. Chim. Acta108: 179–188.
MuralA.,MiyaharaT.,FujimotoN.,MatsudaM. andKamcyomoM. (1986): Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction - Atherosclerosis59: 199–204.
ParraH.J.,LiyéyéI.,BouramouéC.,DemarquillyC. andFruchartJ.C. (1987): Blook white differences in serum Lp(a) lipoprotein levels - Clin. Chim. Acta167: 27–31.
RhoadsG.G.,MortonN.E.,GubrandsenC.L. andKaganA. (1978): Sinking pre-beta lipoprotein and coronary heart disease in Japanese-American men in Hawaii - Am. J. Epidemiol108: 350–356.
WidhalmK. andGenserD. (1988): Increased lipoprotein (a) levels in children with familial hypercholesterolemia - The Lancet Nov.26: 1262.
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Bihari-Varga, M., Kostner, G. & Czinner, A. LP(A) and the risk of coronary heart disease. Eur J Epidemiol 8 (Suppl 1), 33–35 (1992). https://doi.org/10.1007/BF00145347
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DOI: https://doi.org/10.1007/BF00145347