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Serum alpha fetoprotein in 714 mentally retarded carriers of hepatitis B surface antigen


Sera from 714 mentally retarded carriers of hepatitis B surface antigen were screened for alpha fetoprotein (AFP) by monoclonal radioimmunoassay. Serum AFP levels were less than 20 mcg/L in 708 (99.2%) carriers. One 29-year-old carrier with normal liver function had serum AFP level of 1500 mcg/L, which increased to 12,500 mcg/L after 72 days. She died of multifocal hepatocellular carcinoma (HCC) with cirrhosis. Five other carriers with serum AFP levels between 20 and 165 mcg/L are alive without clinical HCC. No correlation was found between serum AFP level and race, age, sex, Down's syndrome, serum alanine aminotransferase level, and hepatitis B e antigen positivity. Single cross-sectional serum AFP screening by itself is not sufficient for early diagnosis of HCC.

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  1. BeasleyR., HwangL., LinC. et al. (1981): Hepatocellular carcinoma and hepatitis B virus. - Lancet 1: 1129–1133.

    Google Scholar 

  2. BelletD., WandsJ., IsselbacherK. et al. (1984): Serum alpha fetoprotein levels in human disease: Perspective from a highly specific monoclonal radioimmunoassay. - Proc. Natl. Acad. Sci. USA 81: 3869–3873.

    Google Scholar 

  3. HeywardW., LanierA., MacMahonB. (1985): Early detection of hepatocellular carcinoma. - JAMA 254: 3052–3054.

    Google Scholar 

  4. Immunization Practices Advisory Committee, Centers for Disease Control Recommendations: Inactivated Hepatitis B Virus Vaccine (1982). - MMWR 31: 317–328.

    Google Scholar 

  5. LohiyaS., LohiyaG., CairesS. (1986): Epidemiology of Hepatitis B infection in institutionalized mentally retarded clients. - Am. J. Public. Health 76: 799–802.

    Google Scholar 

  6. LohiyaG., LohiyaS., CairesS. et al. (1986): Occupational risk of hepatitis B from institutionalized HBsAg carriers: A prospective study. - J. Inf. Dis. 154: 990–995.

    Google Scholar 

  7. LohiyaG., PirkleH., HoefsJ. et al. (1985): Hepatocellular carcinoma in mentally retarded HBsAg carriers without cirrhosis. - Hepatology 5: 824–826.

    Google Scholar 

  8. LutwikL. (1979): Relation between aflatoxin, hepatitis B virus, and hepatocellular carcinoma. -Lancet 1: 755–757.

    Google Scholar 

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Department of Pathology, University of California, Irvine, CA 92717

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Lohiya, G., Lohiya, S., Fischer, T. et al. Serum alpha fetoprotein in 714 mentally retarded carriers of hepatitis B surface antigen. Eur J Epidemiol 4, 181–184 (1988).

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Key words

  • Alpha fetoprotein
  • Hepatocellular carcinoma
  • Hepatitis B