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Electrophysiological evidence that early glaucoma affects foveal vision

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Abstract

The pattern electroretinogram (PERG) and visual evoked potential (PVEP) were recorded simultaneously using a 1.1 cpd pattern which was counterphase modulated at 1 Hz. The responses of ocular hypertensive (OHT) eyes (with normal visual fields) and eyes with early glaucoma (with early visual field defects and/or early cupping of the optic nervehead) were compared to age-matched normal observers. All patients (26 eyes) and normal observers (14 eyes) had normal transient flash electroretinograms. Delays were seen in mean PERG latency in both OHT and early glaucoma eyes, while mean PERG amplitude was significantly reduced only in the early glaucoma eyes. The PVEP responses were ‘unmeasurable’ in 11/26 patient eyes because the waveforms were grossly abnormal in shape, making it impossible to identify the N- and P-components. The data were categorized in this manner: a patient response was considered abnormal if latency or amplitude exceeded normal limits (PERG or PVEP) or if the waveform was ‘unmeasurable’ due to its shape (PVEP only). Of the 26 patient eyes, we found that 8 eyes had normal PERG and PVEP, 11 eyes had abnormal PERG and PVEP, one eye had an abnormal PERG and a normal PVEP, and 6 eyes (3 patients) had a normal PERG and an abnormal PVEP. These data support the proposition that foveal vision (as assessed by the PVEP) may be affected by early glaucomatous damage. The relationship between the PERG and PVEP also was evaluated using a new measurement which we call the ‘latency window’. Using this measurement, 15/26 patient eyes were abnormal - 9 of these had ‘unmeasurable’ PVEPs. This measurement could be useful in classifying ‘W’-shaped PVEPs as normal or abnormal.

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Authors and Affiliations

  1. the Departments of Ophthalmology, The VEP Laboratory, New York City, NY, USA

    Marcia S. Marx, Ivan Bodis-Wollner M.D., Jacqueline S. Lustgarten & Steven M. Podos

  2. the Department of Neurology of the Mount Sinai School of Medicine, The VEP Laboratory, New York City, NY, USA

    Ivan Bodis-Wollner M.D.

Authors
  1. Marcia S. Marx
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  2. Ivan Bodis-Wollner M.D.
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  3. Jacqueline S. Lustgarten
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  4. Steven M. Podos
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Additional information

This study was supported in part by Grants EY01708 and EY01867 from the National Eye Institute, Bethesda, MD, by Fight For Sight Grant-in-Aid G-274, and by an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY.

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Marx, M.S., Bodis-Wollner, I., Lustgarten, J.S. et al. Electrophysiological evidence that early glaucoma affects foveal vision. Doc Ophthalmol 67, 281–301 (1987). https://doi.org/10.1007/BF00144282

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  • DOI: https://doi.org/10.1007/BF00144282

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