Abstract
The electroretinogram (ERG) was recorded 20 times over a period of 360 days in 26 albino-rats with implanted intravitreal iron wires ranging in size between 0.15 and 1.2 mm2. Results: (i) The a- and b-wave amplitudes decreased rapidly within one day after iron wire implantation. During the following week the amplitudes recovered to some extent. In the course of the next few months the a- and b-wave amplitudes of the eyes implanted with the largest iron wires (1.2 mm2) decreased steadily to about 20% by the end of the observation time, whereas in the groups containing smaller iron wires the electroretinographic changes were limited. (ii) Implantation of equally-sized glass splinters reduced the a- and b-wave amplitudes to 65–75% in comparison to the intact fellow eye. Fast recovery of both potentials to 83–93% followed within two weeks. The mean values of the a-wave amplitudes reached nearly 100%, those of the b-wave 90–95% in the next month.
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Schmidt, J.G.H., Max, M. Surface area sizes of intravitreal iron wires: Their effects on the electroretinograms of rats. Doc Ophthalmol 67, 263–272 (1987). https://doi.org/10.1007/BF00144280
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DOI: https://doi.org/10.1007/BF00144280