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Feline leukemia virus: current status of the feline induced immune depression and immunoprevention

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Abstract

This is a review of the current knowledge of feline leukemia virus (FeLV) associated with immune depression observed in cats. It will focus on the clinical and experimental observations associated with feline retroviral infection and presence in vivo and in vitro. We will briefly describe retroviral-associated acquired immune deficiency syndrome associated with FeLV infection in the cat and specific cellular pathology associated with FeLV latency. In addition, we will focus on the action of FeLV-p15E in vitro and describe possible mechanisms of the FeLV-associated immunosuppression observed both in vivo and in vitro. Lastly, we will evaluate the current status of immunoprevention of FeLV. We will not attempt an in-depth analysis of the current literature; our focus is to review current findings as they relate to feline AIDS and immunotherapy.

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Authors and Affiliations

  1. Ohio State University, Ohio

    Richard G. Olsen & Lawrence E. Mathes

  2. Department of Veterinary Pathobiology, Columbus, Ohio

    Richard G. Olsen & Lawrence E. Mathes

  3. Comprehensive Cancer Center, Columbus, Ohio, USA

    Richard G. Olsen, Mark G. Lewis & Lawrence E. Mathes

  4. Norden Laboratories, Research & Development Department, Lincoln, Nebraska, USA

    Keith Haffer & Richard Sharpee

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  1. Richard G. Olsen
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Olsen, R.G., Lewis, M.G., Lafrado, L.J. et al. Feline leukemia virus: current status of the feline induced immune depression and immunoprevention. Cancer Metast Rev 6, 243–260 (1987). https://doi.org/10.1007/BF00144266

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