Documenta Ophthalmologica

, Volume 53, Issue 1, pp 51–60 | Cite as

Abnormal spectral sensitivity of the electroretinographic off-response in protanopia and protanomalia

  • K. Kawasaki
  • D. Yonemura
  • H. Nakazato
  • I. Kawaguchi


The mean of the spectral sensitivity of the rapid off-response in the ERG is significantly lower at 560 nm and longer wavelengths (p < 0.005) in protanopia and protanomalia, as compared with normal control subjects.

Key words

ERG off-response protanopia protanomalia colour blind spectral sensitivity 


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  1. Boettner EA and Wolter JR (1962) Transmission of the ocular media. Invest Ophthal 1:776–783Google Scholar
  2. Brown PK and Wald G (1964) Visual pigments in single rods and cones of the human retina. Science 144:45–52Google Scholar
  3. Copenhaver RM and Gunkel RD (1959) The spectral sensitivity of color-defective subjects determined by electroretinography. Arch Ophthal 62:55–68Google Scholar
  4. Coren S and Girgus JS (1972) Density of human lens pigmentation: in vivo measures over an extended age range. Vision Res 12:343–346Google Scholar
  5. François J, Verriest G and De Rouck A (1960) New electroretinographic findings obtained in congenital forms of dyschromatopsia. Brit J Ophthal 44:430–435Google Scholar
  6. Goodman G and Bornschein H (1957) Comparative electroretinographic studies in congenital night blindness and total color blindness. Arch Ophthal 58:174–182Google Scholar
  7. Kawasaki K, Yonemura D, Nakazato H, Wakabayashi K, Shirao Y and Sakai N (1980) Analysis of rapid off-response in electroretinogram. Major participation of receptor potential. Acta Soc Ophthal Jpn 84:1574–1580Google Scholar
  8. König A and Dieterici C (1886) Grundempfindungen und ihre Intensitäts-Verteilung im Spektrum. S.B. Acad Wiss Berlin 805–829. [Cited from Alpern M (1981) The color vision of the color blind. Jpn J Ophthal 25:1–17]Google Scholar
  9. Marks WB (1965) Visual pigments of single goldfish cones. J Physiol 178:14–32Google Scholar
  10. Marks WB, Dobelle WH and MacNichol EF (1964) Visual pigments of single primate cones. Science 143:1181–1183Google Scholar
  11. Rushton WAH (1958) Visual pigments in the colour blind. Nature 182:690–692Google Scholar
  12. Rushton WAH (1963a) A cone pigment in the protanope. J Physiol 168:345–359Google Scholar
  13. Rushton WAH (1963b) The density of chlorolabe in the foveal cones of the protanope. J Physiol 168:360–373Google Scholar
  14. Rushton WAH (1965) A foveal pigment in the deuteranope. J Physiol 176:24–37Google Scholar
  15. Rushton WAH (1975) Visual pigments and color blindness. Sci Amer 232 (3):64–74Google Scholar
  16. Said FS & Weale RA (1959) The variation with age of the spectral transmissivity of the living human crystalline lens. Gerontologia 3:213–231Google Scholar
  17. KEWP (1971) Vision in the ultraviolet. Thesis, Univ. of Utrecht. [Cited from Norren DV and Vos JJ (1974) Spectral transmission of the human ocular media. Vision Res 14:1237–1244]Google Scholar
  18. Tomita T, Kaneko A, Murakami M and Pautler EL (1967) Spectral response curves of single cones in the carp. Vision Res 7:519–531Google Scholar
  19. Ui K (1975) Photopic electroretinogram: Part I. Studies on normal and color blind subjects. Jpn J Ophthal 19:57–68Google Scholar
  20. Uji Y (1975) The effects of adsorption of visible light in the human lens on the electroretinogram. I. Absorption spectra of lenses. Acta Soc Ophthal Jpn 79:1154–1162Google Scholar
  21. Yasuma T, Ichikawa H and Tanabe S (1978a) Studies on spectral sensitivity curves of the cone pigments. Acta Soc Ophthal Jpn 82:627–634Google Scholar
  22. Yasuma T, Yanagida K, Ichikawa H and Tanabe S (1978b) Isolation of anomalous cone pigments. (I) Isolation of normal cone pigments. Acta Soc Ophthal Jpn 82:759–766Google Scholar
  23. Yokoyama M, Yoshida T and Ui K (1973) Spectral responses in the human electroretinogram and their clinical significance. Jpn J Ophthal 17:113–124Google Scholar
  24. Yonemura D (1977) An electrophysiological study on activities of neuronal and non-neuronal retinal elements in man with reference to its clinical application. Acta Soc Ophthal. Jpn 81:1632–1665Google Scholar
  25. Yonemura D and Kawasaki K (1978) Electrophysiological study on activities of neuronal and non-neuronal retinal elements in man with reference to its clinical application. Jpn J Ophthal 22:195–213Google Scholar
  26. Yonemura D and Kawasaki K (1979) New approaches to ophthalmic electrodiagnosis by retinal oscillatory potential, drug-induced responses from retinal pigment epithelium and cone potential Docum Ophthal 48:163–222Google Scholar
  27. Yoshida T, Uji Y, Kobayashi Y and Kihira Y (1979) Property of the photopic monochromatic ERG in congenital color blindness. Folia Ophthal Jpn 30:690–700Google Scholar

Copyright information

© Dr W. Junk Publishers 1982

Authors and Affiliations

  • K. Kawasaki
    • 1
  • D. Yonemura
    • 1
  • H. Nakazato
    • 1
  • I. Kawaguchi
    • 1
  1. 1.Department of OphthalmologySchool of Medicine, Kanazawa UniversityIshikawaJapan

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