Abstract
The corneal endothelium was examined in ten patients suffering from ocular hypertension before, during and after four months of topical levobunolol treatment. The untreated fellow eye served as a control. The number of endothelial cells, determined with a McIntyre eyepiece and an Eisner's contact lens, was not affected by levobunolol therapy. In addition, the morphology of the cell did not appear to be affected by the drug.
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References
Gaster, RN, Leopold, IH. Topical ophthalmic medications that cause corneal alterations. Biomedical Foundations of Ophthalmology 1982; Vol. 3, Ch. 46, p. 4.
Van Buskirk, EM. Adverse reactions from timololo administration. Ophthalmology 1980; 87: 447–450.
Williams, D, Staaz, P, Ronald, L, Radius, M. Effect of timolol on bovine corneal endotelial cultures. Arch Ophthalmol 1981; 99: 660–63.
Brien, WA, Hay, GJ, Wusan, GM, Willis, WE. Ultrastructural effect of topical timolol on the rabbit cornea. Arch Ophthalmol 1983; 101: 310–14.
Krieglstein, GK, Novack, CD, Voepel, E, Schwarzbach, G. Levobunolol and metipranololo: comparative ocular hypotensive efficacy, safety, and comfort. Br J Ophthalmol 1987; 71: 250–53.
Berson, FG, Cohen, HB, Foerster, RJ, Lass, JH, Nonack, GD, Duzman, E. Levobunolol compared with timolol for the long-term control of elevated intraocular pressure. Arch Ophthalmol 1985; 103: 379–82.
Bensinger, RE, Keates, EV, Gofman, JD, Novach, GD, Duzman, E. Levobunolol: a three-month efficacy study in the treatment of glaucoma and ocular hypertension. Arch Ophthalmol 1985; 103: 375–78.
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Fusco, R., Del Prete, A., Gravina, A. et al. Topically applied levobunolol does not cause changes in the corneal endothelium. Doc Ophthalmol 76, 273–277 (1990). https://doi.org/10.1007/BF00142686
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DOI: https://doi.org/10.1007/BF00142686