Abstract
Antibiotic production by submerged cultures of Penicillium urticae required manganese supplementation of the media. Thus, manganese supplementation (152 μM) allowed accumulation of patulin to high concentrations (2 μmol/mL), whereas manganese deficiency (1.53 μM) resulted in the accumulation to similar levels of the first committed pathway intermediate, methyl-salicylic acid, without significant patulin accumulation. Preliminary studies suggest that a similar manganese effect may occur in other fungal species.
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Scott, R.E., Jones, A. & Gaucher, G.M. A manganese requirement for patulin biosynthesis by cultures of Penicillium urticae. Biotechnol Lett 6, 231–236 (1984). https://doi.org/10.1007/BF00140042
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DOI: https://doi.org/10.1007/BF00140042