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Carriers of X-linked recessive retinitis pigmentosa: investigation by vitreous fluorophotometry

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Abstract

The blood-retinal barrier was assessed by vitreous fluorophotometry in nine carriers of X-linked recessive retinitis pigmentosa. A breakdown of the blood-retinal barrier was apparent in all patients. In one carrier, the barrier was compromised even when abnormalities were not apparent in the retina ophthalmoscopically or by electroretinogram testing. The degree of abnormality of the blood-retinal barrier tended to parallel the extent of abnormalities noted on ophthalmoscopy, visual field examination, and electroretinogram testing.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Illinios Hospital Eye and Ear Infirmary University of Illinios at the Medical Center, Chicago, Ill., USA

    Gerald A. Fishman & Jose E. Cunha-Vaz

Authors
  1. Gerald A. Fishman
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  2. Jose E. Cunha-Vaz
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Additional information

This investigation was supported in part by core grant IP30EY01792 and by grant EY-703802 from the national Eye Institute, National Institutes of Health, Bethesda, Maryland; by an unrestricted grant and Manpower award from Research to Prevent Blindness, Inc. NYC; and by a research grant from the National Retinitis Pigmentosa Foundation, Baltimore, Maryland.

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Fishman, G.A., Cunha-Vaz, J.E. Carriers of X-linked recessive retinitis pigmentosa: investigation by vitreous fluorophotometry. Int Ophthalmol 4, 37–44 (1981). https://doi.org/10.1007/BF00139579

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