Summary
The resolution of racemic citronellol and menthol by enzymatically catalyzed transesterification in supercritical carbon dioxide (SC-CO2) was investigated. Different lipases and an esterase in connection with various acylating reagents were employed. While the transesterification of (±)-menthol was reasonably fast and gave high enantiomeric excess, resolution of (±)-citronellol was not feasible.
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Michor, H., Marr, R., Gamse, T. et al. Enzymatic catalysis in supercritical carbon dioxide: Comparison of different lipases and a novel esterase. Biotechnol Lett 18, 79–84 (1996). https://doi.org/10.1007/BF00137815
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DOI: https://doi.org/10.1007/BF00137815