Abstract
The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.
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Alghadyan, A.A., Peyman, G.A., Khoobehi, B. et al. Liposome-bound cyclosporine: Clearance after intravitreal injection. Int Ophthalmol 12, 109–112 (1988). https://doi.org/10.1007/BF00137135
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DOI: https://doi.org/10.1007/BF00137135