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Synthesis of β-galactosyl-(hydroxy amino acid) derivatives using β-galactosidase activity ofAchatina achatina digestive juice

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Summary

The transglycosylation activity of β-galactosidase fromAchatina achatina digestive juice was tested for glycosylating protected hydroxy amino acids. Attractive yields of β-galactosyl-(Z-Ser-OMe) (35%) and β-galactosyl-(Z-Hyp-OMe) (28%) could be obtained using lactose as glycosyl donor and the corresponding amino acid methyl esters N-protected by a benzyloxycarbonyl group (Z) as glycosyl acceptors.

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Authors and Affiliations

  1. Faculté des Sciences et des Techniques, Laboratoire d'Enzymologie, Centre de Recherche de Biologie et Physico-Chimie Cellulaires, 2 rue de la Houssinière, 44072, Nantes Cedex 03, France

    Sylvie Leparoux, Yannick Fortun & Bernard Colas

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  1. Sylvie Leparoux
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  2. Yannick Fortun
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  3. Bernard Colas
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Leparoux, S., Fortun, Y. & Colas, B. Synthesis of β-galactosyl-(hydroxy amino acid) derivatives using β-galactosidase activity ofAchatina achatina digestive juice. Biotechnol Lett 16, 677–682 (1994). https://doi.org/10.1007/BF00136470

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  • DOI: https://doi.org/10.1007/BF00136470

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