Summary
The kinetics of the oxidation of glutathione by diaquatetrakis(2,2′-bipyridine)-μ-oxo diruthenium(III) ion in aqueous HClO4 have been investigated. The reaction obeys the empirical rate law:-2d[oxidant]/dt = k[oxidant][reductant]/[H+] where k = 7.42 ± 0.40 × 10-3 s-1 at 25.5 °C, [H+] = 0.005–0.05 M and I = 1.0 M (LiClO4). Free radicals are important in the reaction and a mechanism consistent with the experimental results has been postulated.
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Ayoko, G.A., Iyun, J.F. & Ekubo, A.T. Oxidation of glutathione by diaquatetrakis(2,2′-bipyridine)-μ-oxo diruthenium(III) ion in aqueous acidic solutions. Transition Met Chem 18, 6–8 (1993). https://doi.org/10.1007/BF00136039
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DOI: https://doi.org/10.1007/BF00136039