Summary
In this paper an alternative to the stirred tank type of bioreactors is presented, which is characterized by a low ratio of liquid-to-gas-volume. In different constructions high interfacial areas are created by thin layers of liquid at low degree of “hinterland” in the liquid phase. The physical characteristics like fluid dynamics, OTR, mixing and the degree of hinterland are discussed together with some applications to bioprocessing. In conclusion, the interesting features of thin-layer-bioreactors for proper process kinetic analysis are recognized.
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Moser, A. Bioreactors with thin-layer characteristics. Biotechnol Lett 4, 281–286 (1982). https://doi.org/10.1007/BF00132826
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DOI: https://doi.org/10.1007/BF00132826