Abstract
The effect of both regular silicone and fluorosilicone in preventing retinal detachment caused by experimental proliferative vitreoretinopathy was studied in rabbit eyes which received 250,000 fibroblasts after vitrectomy and lensectomy. In the control group, 14 out of 20 eyes which received fibroblasts had retinal detachments with disorganization of internal structures. In eyes receiving fibroblast and regular silicone, 4 out of 20 eyes had shallow retinal detachment. In the eyes receiving fibroblasts and fluorosilicone, 5 of 28 eyes had shallow retinal detachment. Our findings indicate that both regular silicone and fluorosilicone were effective in preventing retinal detachments caused by experimental proliferative vitreoretinopathy. There was no statistical difference between the two silicone oils.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Armaly MF. Ocular tolerance to silicones, I. Replacement of aqueous and vitreous by silicone fluids. Arch Ophthalmol 1962; 68: 390–395.
Chan C, Okun E. The question of ocular tolerance to intravitreal liquid silicone: A long term analysis. Ophthalmology 1986; 93: 651–660.
Cox MS, Trese MT, Murphy PL. Silicone oil for advanced proliferative vitreoretinopathy, Ophthalmology 1986; 93: 646–650.
Gonvers M, Thresher R. Temporary use of silicone oil in the treatment of proliferative vitreoretinopathy: An experimental study with a new animal model. Graefe's Arch Clin Exp Ophthalmol 1983; 221: 46–53.
Labelle P, Okun E. Ocular tolerance to liquid silicone: An experimental study. Can J Ophthalmol 1972; 7: 199–203.
Lean JS, Van Der Zee WAM, Ryan SJ. Experimental model of proliferative vitreoretinopathy (PVR) in vitrectomised eyes: Effect of silicone. Br J Ophthalmol 1984; 68: 332–335.
Lee PF, Donovan RH, Mukai N et al. Intravitreous injection of silicone: An experimental study, I. Clinical picture and histology of the eye. Ann Ophthalmol 1969; 1: 15–25.
Levine AM, Ellis RA. Intraocular liquid silicone implants. Am J Ophthalmol 1963; 55: 939–943.
Mukai N, Lee PF, Oguri M, Schepens CL. A long-term evaluation of silicone retinopathy in monkeys. Can J Ophthalmol 1975; 10: 391–402.
Mukai N, Lee PF, Schepens CL. Intravitreous injection of silicone: An experimental study, II. Histochemistry and Electron Microscopy. Ann Ophthalmol 1972; 4: 273–287.
Ober RR, Blanks JC, Ogden TE et al. Experimental retinal tolerance to liquid silicone. Retina 1983; 3: 77–85.
Petersen J, Ritzau-Tondrow U, Vogel M. Fluor-Silikonol schwerer als Wasser: ein neues Hilfsmittel der vitreo/retinalen Chirurgie. Klin Mbl Augenheilk 1986; 189: 228–232.
Siguta G, Tano Y, Machamer R et al. Intravitreal auto transplantation of fibroblasts. Am J Ophthalmol 1980; 89: 121.
Sterns W, Fisher S, Anderson D et al. Epiretinal membrane formation after vitrectomy. Am J Ophthalmol 1982; 93: 757–772.
Author information
Authors and Affiliations
Additional information
Supported in part by Public Health Service Grant EYO 2377, from the National Eye Institute, National Institutes of Health, Bethesda, MD.
Rights and permissions
About this article
Cite this article
Alghadyan, A., Peyman, G.A., Fizer, C. et al. Regular silicone and fluorosilicone oil in the prevention of retinal detachment caused by experimental proliferative vitreoretinopathy. Int Ophthalmol 11, 171–174 (1988). https://doi.org/10.1007/BF00130619
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00130619