Conclusion
These examples demonstrate the usefulness of embryonic neurons for investigation ofneurotropic virus pathogenesis studies. The different steps of viral interactions of neurotropicviruses with the brain necessitate studies of the intrinsic neural properties of the infected cells:1) entry of virus into the intra-cellular compartment, 2) transport of virus from one brainstructure to another brain area, 3) replication of virus in the host-cells, 4) altered brainfunctions. Understanding the mechanisms of neural pathogenesis is a prerequisite for theelaboration of antiviral strategies based upon recovery of the brain from functional alterationsusing drugs active on brain functions.
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Tsiang, H. Virus-neuron interaction: an experimental model. Cell Biol Toxicol 8, 101–105 (1992). https://doi.org/10.1007/BF00130516
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DOI: https://doi.org/10.1007/BF00130516