Summary
Biosynthesis of 1-acetyl-β-carboline, an enzyme inhibitor, in S. kasugaensis SK-619 was regulated by quality of the carbon source and by addition of organic acids into medium. Variation in phosphate concentration also affected production of this carboline.
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Desforges, C., Venault, P., Doos, R.H., Chaponnthier, G., and Roubetoux, P.L. (1989) Pharmacol.Biochem.Behav. 34, 733–737.
Kaneda, M., Kitahara, T., Yamasaki, K., Nakamura, S. (1990) J. Antibiot. 43, 1623–1626.
Nozawa, K., Udagawa, S., and Nakajima, K. (1989) Phytochemistry 28, 929–930.
Pažoutová, S., and Řeháček, Z. (1984) Appl.Microbiol.Biotechnol. 20, 389–392.
Proksa, B., Uhrín, D., Šturdíková, M., and Fuska, J. (1990) Acta Biotechnol. 10, 337–340.
Reshetilova, T.A.,and Kozlovskii, A.G. (1990) Prikl.Biokhim.Mikrobiol. 26, 291–306.
Rommelspacher, H., May, T., and Susilo, R. (1991) Planta Med. Supplement Issue 1, 57, 85–92.
Spalla, C., Filippini, S., and Grein, D. (1978) Folia Microbiol. 23, 505–508.
Šturdíková, M., Proksa, B., Uhrín, D., and Fuska, J. (1990) Folia Microbiol. 35, 278–283.
Šturdíková, M., Proksa, B., and Fuska, J. (1993) unpublished results.
Vining, L.C., and Chatterjee, S. (1982) in Overproduction of Microbial Products, V. Krumphanzl, B. Sikyta and Z. Vaněk, eds. p. 35, London, Academic Press.
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Šturdíková, M., Proksa, B. & Fuska, J. Regulation of biosynthesis of 1-acetyl-β-carboline in Streptomyces kasugaensis . Biotechnol Lett 15, 1237–1242 (1993). https://doi.org/10.1007/BF00130304
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DOI: https://doi.org/10.1007/BF00130304