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Enantioselective oxidations catalyzed by diketocamphane monooxygenase from Pseudomonas putida with macromolecular NAD in a membrane reactor

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Summary

Several sulfides and bicyclo[3.2.0]hept-2-en-6-one were enantioselectively oxidized to the corresponding sulfoxides and oxa lactones by a crude preparation of the two diketocamphane monooxygenases from Pseudomonas putida. The reactions were carried out in a membrane reactor with the use of poly(ethylene glycol)-N6-(2-aminoethyl)-NAD and coenzyme regeneration by the formate/formate dehydrogenase system.

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Authors and Affiliations

  1. Istituto di chimica degli Ormoni, C.N.R., Via Mario Bianco 9, 20133, Milano, Italy

    Piero Pasta & Giacomo Carrea

  2. Istituto di Chimica Organica, Facoltà di Farmacia, Universitá di Milano, Via Venezian 21, 20133, Milano, Italy

    Nicoletta Gaggero

  3. Department of Biological Sciences, University of Exeter, EX4 4QG, Exeter, UK

    Gideon Grogan & Andrew Willetts

Authors
  1. Piero Pasta
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  2. Giacomo Carrea
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  3. Nicoletta Gaggero
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  4. Gideon Grogan
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  5. Andrew Willetts
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Pasta, P., Carrea, G., Gaggero, N. et al. Enantioselective oxidations catalyzed by diketocamphane monooxygenase from Pseudomonas putida with macromolecular NAD in a membrane reactor. Biotechnol Lett 18, 1123–1128 (1996). https://doi.org/10.1007/BF00128578

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  • DOI: https://doi.org/10.1007/BF00128578

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