Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

Summary

Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of upases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.

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Goto, M., Noda, S., Kamiya, N. et al. Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media. Biotechnol Lett 18, 839–844 (1996). https://doi.org/10.1007/BF00127899

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Keywords

  • Ester
  • Surfactant
  • Enzymatic Activity
  • Organic Chemistry
  • Lipase