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Étude de l'action de l'aminoptérine sur la recombinaison génique chez Drosophila melanogaster

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Abstract

Study of the action of aminopterin on genic recombination in Drosophila melanogaster—A study was made of the action, during meiosis, of aminopterin, inhibitor of nucleotide metabolism. An increase of the rate of crossing over was observed. This increase was studied on two systems, by using highly linked markers, so as to minimize the amount of double crossing over: vg-su, on chromosome II and y-w a, on the X chromosome.

It is shown that aminopterin induces a significant increase of recombination. The independence of the two systems makes plausible that aminopterin could act on the whole genome at a meiotic level.

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Authors and Affiliations

  1. Laboratorie de Génétique des Populations, Université Paris VII, Tour 42, Sième étage, 2 Place Jussieu, 75251, Paris Cedex 05, France

    C. Bazin, J. Silber & J. M. Goux

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  1. C. Bazin
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  2. J. Silber
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  3. J. M. Goux
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Bazin, C., Silber, J. & Goux, J.M. Étude de l'action de l'aminoptérine sur la recombinaison génique chez Drosophila melanogaster . Genetica 60, 119–122 (1983). https://doi.org/10.1007/BF00127497

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  • DOI: https://doi.org/10.1007/BF00127497

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