Skip to main content
SpringerLink
Log in

The structure-activity relationship of inhibitors of serotonin uptake and receptor binding

  • Research Papers
  • Published:
Journal of Computer-Aided Molecular Design Aims and scope Submit manuscript

Summary

An analysis of five different datasets of inhibitors of serotonin uptake has yielded quantitative structure/ activity relationships (QSARs) which delineate the role of steric and hydrophobic properties essential for inhibition by phenylethylamine-type analogues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hansch, C. and Fujita, T., J. Am. Chem. Soc., 86 (1964) 1616.

    Google Scholar 

  2. Topliss, J.G., Quantitative Structure-Activity Relationships of Drugs, Academic Press, New York, 1983.

    Google Scholar 

  3. Fujita, T., In Jolles, G. and Wooldridge, K.R.H. (Eds.), Drug Design: Fact or Fantasy? Academic Press, New York, 1984, pp. 19–53.

    Google Scholar 

  4. Hansch, C. and Leo, A., Substituent Constants for Correlation Analysis in Chemistry and Biology, Wiley-Interscience, New York, 1979.

    Google Scholar 

  5. Martin, Y.C., Quantitative Drug Design, Marcel Dekker, New York, 1978.

    Google Scholar 

  6. Fauchere, J.L., QSAR: Quantitative Structure-Activity Relationships in Drug Design, Alan R. Liss, New York, 1989.

    Google Scholar 

  7. Richter, A. and Smith, S.E., J. Pharm. Pharmacol., 26 (1974) 763.

    Google Scholar 

  8. Hansch, C. and Klein, T., Acc. Chem. Res., 19 (1986) 392.

    Google Scholar 

  9. Martin, L.L., Roland, D.M., Neale, R.F. and Wood, P.L., Eur. J. Pharmacol., 132 (1986) 53.

    Google Scholar 

  10. Högberg, T., Ulff, B., Renyi, A.L. and Ross, S.B., J. Med. Chem., 24 (1981) 1499.

    Google Scholar 

  11. Taylor, E.W., Nikam, S.S., Lambert, G., Martin, A.R. and Nelson, D.L., Mol. Pharmacol., 34 (1988) 42.

    Google Scholar 

  12. Leo, A., J. Chem. Soc. Perk. Trans. II, (1983) 825.

    Google Scholar 

  13. Glennon, R.A., Young, R., Benington, F. and Morin, R.D., J. Med. Chem., 25 (1982) 1163.

    Google Scholar 

  14. Fujita, T., Iwasa, J. and Hansch, C., J. Am. Chem. Soc., 86 (1964) 5175.

    Google Scholar 

  15. Selassie, C.D., Strong, C.D., Hansch, C., Delcamp, T.J., Freishein, J.H. and Khwaja, T.A., Cancer Res., 46 (1986) 744.

    Google Scholar 

  16. Coats, E.A., Genther, C.S., Selassie, C.D., Strong, C.D. and Hansch, C., J. Med. Chem., 28 (1985) 1910.

    Google Scholar 

  17. Selassie, C.D., Hansch, C. and Khwaja, T.A., J. Med. Chem., 33 (1990) 1914.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Pomona College, 91711, Claremont, CA, U.S.A.

    Corwin Hansch & Jonathan Caldwell

Authors
  1. Corwin Hansch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jonathan Caldwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hansch, C., Caldwell, J. The structure-activity relationship of inhibitors of serotonin uptake and receptor binding. J Computer-Aided Mol Des 5, 441–453 (1991). https://doi.org/10.1007/BF00125664

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00125664

Key words

Search

Navigation