Abstract
Although univalents in diakinesis are often used as an estimator for chromosome mis-segregation during meiosis, no clear-cut relationship was demonstrated between both phenomena. In this study, the frequencies of autosomal and gonosomal univalents in diakinesis were related to the frequencies of aneuploid metaphase-II gonocytes during spermatogenesis and oogenesis of different mouse strains and their hybrids (inbred strains: DBA/2J, C57Bl; outbred strain; Swiss, inbred x outbred hybrids: Swiss × C57Bl, C57Bl × Swiss, inbred x inbred hybrids: DBA/2J × C57Bl, C57Bl × DBA/2J). As far as the frequencies of univalents are concerned, they were shown to be strain-dependent and similar in both sexes. Moreover, there is a high non-disjunction rate of DBA males and PMSG-HCG-primed DBA females. Aneuploidy in metaphase II is also strain-dependent but different in both sexes; in the male, a clear decrease of aneuploidy frequencies is observed as compared to the frequency of univalents. This decrease does not occur in females.
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Léotard, D., Kirsch-Volders, M., Alexandre, H. et al. Relationship between frequencies of univalents and meiotic segregation in different mouse strains and their hybrids. Genetica 75, 189–198 (1987). https://doi.org/10.1007/BF00123573
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DOI: https://doi.org/10.1007/BF00123573