Timson's (1969, 1970) three locus model for the determination of anencephaly and spina bifida is examined, and it is concluded that observed population incidences of these conditions do not fit the model. A consideration is presented of the relevance of such models to the aetiology of multifactorial disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Carter, C. O., P. A., David & K. M., Lawrence (1968). A family study of major central nervous system malformations in South Wales. J. med. Genet. 5: 81–106.
Czeizel, A. & C., Revesz (1970). Major malformations of the central nervous system in Hungary. Brit. J. prev. Soc. Med. 24: 205–222.
Fagerhol, M. K. & H. E., Hauge (1969). Serum Pi types in patients with pulmonary disease. Acta Allergicologica 24: 107–114.
Falconer, D. S. (1961). Introduction to Quantitative Genetics. Oliver & Boyd, Edinburgh.
Fedrick, J. (1970). Anencephalus and the local water supply. Nature 337: 176.
James, J. W. (1971). Frequency in relatives for an all-or--none trait. Ann. human Genet. 35: 47–50.
Lorber, J. & N. C., De (1970). Family history of congenital hydrocephalus. Dev. Med. Child Neurol. 12 Supp. 22: 94–100.
Morton, N. E., S., Yee, R. C., Elston & R., Lew (1970). Discontinuity and quasi-continuity, alternative models of multifactorial inheritance. Clin. Genet. 1: 81–94.
Nance, W. E. (1969). Anencephaly and spina bifida: a possible example of cytoplasmic inheritance in man. Nature 224: 373–375.
Navarrete, V. N., C. E., Rojas, C. R., Alger & H. E., Paniagua (1976). Subsequent diabetes in mothers delivered of a malformed infant. Lancet 2: 993–995.
Smith, C. (1971). Discriminating between different modes of inheritance in genetic disease. Clin. Genet. (in press).
Timson, J. (1969). The sex ratio in spina bifida. Genetica 40: 427–433.
Timson, J. (1970). The sex ratio in anencephaly. Genetica 41: 457–465.
Vallance-Owen, J. (1966). The inheritance of essential diabetes mellitus from studies of the synalbumin insulin antagonist. Diabetologia 2: 248–252.
W.H.O. Scientific Group (1970). Genetic factors in congenital malformation. Wld. Hlth. Org. tech. Rep. Ser. 438.
Wilson, J. S. P. & J., Vallance-Owen (1967). Congenital deformities and insulin antagonism. Lancet 2: 940–942.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mayo, O. Sex ratio in spina bifida and anencephaly. Genetica 42, 437–444 (1971). https://doi.org/10.1007/BF00122075
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00122075