Skip to main content
SpringerLink
Log in

Composites of hydroxyapatite and bisphosphonate: properties and alveolar bone response

  • Paper
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

A composite was made by adsorption of the bisphosphonate [(3-dimethylamino-1-hydroxypropylidene)-1,1-bisphosphonate; dimethyl-APD] into an hydroxyapatite (HA) tube. Adsorbed dimethyl-APD did not change the bulk properties of the HA tube but the surface properties were altered. The amount of 0.1 mmol/L dimethyl-APD adsorbed into the HA tube was 0.78 ( ± 0.20) μg after 4 weeks. The composite tube of HA and dimethyl-APD placed after extraction of teeth in the premolar regions of dogs were biocompatible, stable and bonded strongly and intimately to the alveolar bone. Although there was no bone resorption around the composite tubes, no conclusion can be drawn yet from this study as far as local inhibition of alveolar bone resorption is concerned.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. W. Denissen, W. Kalk, A. A. H. Veldhuis and A.Van Den Hooff, J. Prosthet. Dent. 61 (1989) 706.

    Google Scholar 

  2. H. W. Denissen and W. Kalk, Int. Dent. J. 41 (1991) 17.

    Google Scholar 

  3. H. Fleisch, in “Bone and mineral research annual 1” (Excerpta Medical, Amsterdam, 1983) p. 319.

    Google Scholar 

  4. R. Valkema, F. J. F. E. Vismans, S. E. Papapoulos, E. K. J. Pauwels and O. L. M. Bijvoet, Bone Miner. 5 (1989) 183.

    Google Scholar 

  5. C. W. G. M. Löwik, G.Van Der Pluym, L. J. A.Van Der Weepals, H. Bloys Van Treslong-De Groot and O. L. M. Bijvoet, J. Bone Miner. Res. 3 (1988 185.

    Google Scholar 

  6. S. E. Papapoulos, O. L. M. Bijvoet, R. Valkema, J. O. Valkman, V. Papapoulos and E. K. J. Pauwels, in “Osteoporosis” (Osteopress ApS, Copenhagen, 1990) p. 1294.

    Google Scholar 

  7. S. E. Papapoulos, K. Hoekman, C. W. G. M. Löwik, P. Vermeij and O. L. M. Bijvoet, J. Bone Miner. Res. 4 (1989) 775.

    Google Scholar 

  8. H. W. Denissen, in “Hydroxyapatite implants” (Piccin, Padua, 1985) p. 39.

    Google Scholar 

  9. P. Ducheyne, S. Radin, M. Heughebaert and J. C. Heughebaert, Biomaterials 11 (1990) 244.

    Google Scholar 

  10. F. B. McFALL and P. K. BAJPAI, in proceedings of the 2nd World Biomaterials Congress on Biomaterials, Washington D.C., May 1984, p. 354.

  11. P. K. Bajpai and H. A. Benghuzzi, J. Biomed. Mater. Res. 22 (1988) 1245.

    Google Scholar 

  12. H. A. BENGHUZZI, B. F. GIFFIN, P. K. BAJPAI and B. G. ENGLAND, in Proceedings of the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, May 1991, p. 53.

  13. S. DOWNES, C. P. A. T. KLEIN, M. V. KAYSER and L. DI SILVIO, in Proceedings of the 4th World Biomaterials Congress, Berlin, April 1992, p. 178.

  14. C. P. A. T. Klein, A. A. Driessen and K.De Groot, J. Biomed. Mater. Res. 17 (1983) 769.

    Google Scholar 

  15. S. E. Papapoulos, J. O. Landman, O. L. M. Bijvoet, C. W. G. M. Löwik, R. Valkema, E. K. J. Pauwels et al., Bone 13 (1992) S 41.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Implantology, Academic Center for Dentistry Amsterdam (ACTA), Louwesweg 1, 1066 EA, Amsterdam, The Netherlands

    H. Denissen

  2. Department of Oral Function and Prosthetic Dentistry. Faculty of Medical Sciences, University of Nijmegen, The Netherlands

    W. Kalk

  3. Department of Endocrinology, University Hospital of Leiden, The Netherlands

    E. Van Beek, C. Löwik & S. Papapoulos

  4. Laboratory for Cell Biology and Histology, School of Medicine, University of Amsterdam, The Netherlands

    A. Van Den Hooff

Authors
  1. H. Denissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Kalk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Van Beek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Löwik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Papapoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Van Den Hooff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Denissen, H., Kalk, W., Van Beek, E. et al. Composites of hydroxyapatite and bisphosphonate: properties and alveolar bone response. J Mater Sci: Mater Med 6, 35–40 (1995). https://doi.org/10.1007/BF00121245

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00121245

Keywords

Search

Navigation