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Effect of cationic groups on the adhesivity of peritoneal macrophages to polymeric beads

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Abstract

This study demonstrates the adhesion of macrophages to polymer beads from a copolymer of hydroxyethyl methacrylate and dimethyl aminoethyl methacrylate intraperitoneally injected into the rat. Dimethyl aminoethyl methacrylate exhibited a stimulatory effect on macrophage adhesion 5 h after injection of the beads. Electron microscopy demonstrated protein adsorption on the surface of the beads. Protein fibres between the cell surface and beads were observed. The experimental system used minimizes the influence of tissue damage at macrophage recognition of polymers. This method seems to be suitable for short-term investigation of macrophage-polymer interaction.

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Authors and Affiliations

  1. Department of Anatomy, First Faculty of Medicine, Charles University, U nemocnice 3, 12800, Prague 2, Czech Republic

    K. Smetana Jr

  2. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague

    M. Jelínková & J. Vacík

  3. Central Military Institute of Medicine, Prague

    M. Novák

Authors
  1. K. Smetana Jr
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  2. M. Jelínková
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  3. J. Vacík
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  4. M. Novák
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Smetana, K., Jelínková, M., Vacík, J. et al. Effect of cationic groups on the adhesivity of peritoneal macrophages to polymeric beads. J Mater Sci: Mater Med 6, 32–34 (1995). https://doi.org/10.1007/BF00121244

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  • DOI: https://doi.org/10.1007/BF00121244

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