Owing to their excellent biocompatibility, silicone elastomers are very often studied to prepare controlled-release systems of therapeutic molecules. In order to produce a loaded matrix, the influence of the physical properties of elastomers on molecule diffusion has to be characterized. In this work the influence of the mesh size on progesterone diffusion was analysed. The results show a very important evolution of the diffusion coefficient, D, in the smallest meshes. On the other hand, in the largest meshes, an increase in the mesh size involves a very slight increase in D, approaching an asymptotic value. In addition to the size, the mesh form has a significant effect on molecule diffusion. Moreover, in the case of a mesh size dispersion the smallest meshes of the network have a fundamental action on the diffusion coefficient of the progesterone.
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Mazan, J., Leclerc, B., Porte, H. et al. Influence of network characterisitics on diffusion in silicone elastomer. J Mater Sci: Mater Med 4, 175–178 (1993). https://doi.org/10.1007/BF00120388
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DOI: https://doi.org/10.1007/BF00120388