When 5 million cells of the ascitic form of the RMT 13762 are injected into syngeneic F344 rat footpads there is consistent metastasis to the popliteal node more rapidly than when the solid form is used. A greater number of tumor cells escapes from the footpad to the draining node via the afferent lymph than with the solid tumor. Local intralymphatic injection of 5FU produces cure or retardation of nodal metastasis in a significant number of animals (p<0–002).
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References
Bogden, A. E., and Esber, H. J., 1978, Influence of surgery, irradiation, chemotherapy and immunotherapy on growth of a metastasizing rat mammary adenocarcinoma. National Cancer Institute Monograph, 49, 97–100.
Bogden, A. E., Esber, H. J., Taylor, D. J., and Gray, J. H., 1974, Comparative study on the effects of surgery, chemotherapy and immunotherapy, alone and in combination, on metastasis of the 13762 mammary adenocarcinoma. Cancer Research, 34, 1627–1631.
Carr, I., Carr, J., and Dreher, B., 1981, Lymphatic metastasis of mammary carcinoma. An experimental study in the rat with a brief review of the literature. Invasion & Metastasis, 1, 34–53.
Carr, J., Carr, I., Dreher, B., and Betts, K., 1980, Lymphatic metastasis, invasion of lymphatic vessels and efflux of tumor cells in the afferent popliteal lymph as seen in the Walker rat carcinoma. Journal of Pathology, 132, 287–305.
Carr, I., and McGinty, F., 1974, Lymphatic metastasis and its inhibition, an experimental model. Journal of Pathology, 113, 85–95.
Kaledin, V. I., Matienko, N. A., Nikolin, V. P., Gruntenko, Y. V., and Budker, V. G., 1981, Intralymphatic administration of liposome-encapsulated drugs to mice. Possibility for the suppression of the growth of tumor metastases in the lymph nodes. Journal of the National Cancer Institute, 66, 881–887.
Plotkin, D., 1980, Chemotherapy of lymph node metastases, differential response. Lymphatic System Metastasis, edited by L. Weiss, H. A. Gilbert and S. C. Ballon (Boston, Mass: G. K. Hall), pp. 200–209.
Takahashi, T., Kong, K., Yamaguchi, T., Watanabe, S., and Majima, S., 1977, Enhancement of chemotherapeutic effect on lymph node metastasis by anticancer agents in fat emulsion. Gann Monograph on Cancer Research, 20, 195–204.
Taylor, D. J., 1976, Predictive mammary tumor test systems for experimental chemotherapy. In, Breast Cancer, Trends in Research and Treatment. A monograph of the European Organization for Research on Treatment of Cancer (New York: Raven Press), pp. 95–110.
Van de Velde, C. J. H., van Putten, L. M., and Zwaveling, A., 1977a, A new metastasizing mammary carcinoma model in mice. Model characteristics and applications. European Journal of Cancer, 13, 555–565.
Van de Velde, C. J. H., van Putten, L. M., and Zwaveling, A., 1977 b, Effects of regional lymphadenectomy and adjuvant chemotherapy on metastasis and survival in rodent tumor models. European Journal of Cancer, 13, 883–895.
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Carr, J., Dreher, B. & Carr, I. Lymphatic metastasis; lymphangiochemotherapy of mammary cancer: ascitic form of rat mammary adenocarcinoma 13762. Clin Exp Metast 1, 29–38 (1983). https://doi.org/10.1007/BF00118470
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DOI: https://doi.org/10.1007/BF00118470