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Abundant postoperative calcification of an elastomer: matrix calcium phosphate-polymer composite for bone reconstruction

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In this experiment the behaviour of an 80/20 PEO/PBT copolymer in bone defeets was assessed. Porous cylinders were press-fit inserted into the diaphyseal femur of goats and evaluated by light and electron microscopy and X-ray microanalysis. The most important finding in this study was that almost complete calcification throughout the implant was displayed after 26 weeks. The 80/20 PEO/PBT copolymer did not contain calcium and phosphorus prior to implantation, however, it apparently has the ability to take up considerable amounts of calcium and phosphate postoperatively, resulting in a calcium phosphate-polymer composite. As a consequence of the high calcification rate of 80/20 cylinders, bone-bonding (a continuum between calcification of the material surface and bone) was encountered as early as 3 weeks after implantation. Union of the 5 mm defect was observed at 6 weeks and ingrowth was frequently centripetal. After 26 weeks bone tissue occupied most of the pore area and was often seen in continuity with the calcified polymer. We conclude that an elastomeric matrix that is capable of abundant postoperative calcification behaves favourably with respect to the repair of bone defects. Porous 80/20 PEO/PBT copolymer is, therefore, a promising alternative for bone-replacement applications.

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Authors and Affiliations

  1. Laboratory of Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Building 55 Rijnsburgeweg 10, 2333 AA, Leiden, The Netherlands

    A. M. Radder & C. A. Van Blitterswijk

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  1. A. M. Radder
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  2. C. A. Van Blitterswijk
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Radder, A.M., Van Blitterswijk, C.A. Abundant postoperative calcification of an elastomer: matrix calcium phosphate-polymer composite for bone reconstruction. J Mater Sci: Mater Med 5, 320–325 (1994). https://doi.org/10.1007/BF00058955

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