Statistical interpretation of results of experiments involving unscheduled DNA synthesis is examined from a design standpoint. Most appropriate methods currently in use are evaluated and some modifications and extensions are suggested. Concerns about replication and/or interaction errors are evaluated and methods for their appropriate handling are discussed. It is suggested that methods incorporating both dose-response and heterogeneity statistics should be considered in treating results from unscheduled DNA synthesis experiments. Proper designs for such experiments are emphasized.
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Abbreviations
- ANOVA:
-
analysis of variance
- MSE:
-
mean square error
- UDS:
-
unscheduled DNA synthesis
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Thakur, A.K. Unscheduled DNA synthesis: Some statistical thoughts. Cell Biol Toxicol 3, 175–192 (1987). https://doi.org/10.1007/BF00058455
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DOI: https://doi.org/10.1007/BF00058455