The action of the Notch locus in Drosophila melanogaster III. Biochemical effects of recessive visible mutations on mitochondrial enzymes

Abstract

The effects of six recessive visible Notch mutations on the activities of four enzymes of the mitochondrial respiratory chain are described. Their effects in hemizygous condition in males are similar to those of the recessive lethal Notch mutations in heterozygous condition. This explains their viability. The characteristic morphological Notch expression cannot be related to the different activity patterns of four enzymes caused by the recessive visible mutations. Whereas there is a correspondence between the location of the recessive lethals and the recessive visibles in relation to their enzyme activity patterns, this is not so in relation to their morphological effects. In contrast to the enzyme activity determinations in heterozygotes for recessive lethals, the effects of recessive visibles are determined in the hemizygous condition, thereby excluding the influence of wildtype Notch alleles. Such an influence is found in heterozygotes for the exceptional fa ^nomutant, in which morphological expression is dependent on the wildtype X chromosome.