Summary
To compare the effects of enalapril and captopril on blood pressure, serum creatinine (S-Cr), and potassium (S-K) levels, patients with malignant hypertension treated with either 5–10 mg of enalapril (eight cases) or 75–400 mg of captopril (eight cases) were investigated retrospectively. After 2 weeks of treatment, the average blood pressure fell from 214/138 to 132/89 mmHg on enalapril and from 240/145 to 147/95 mmHg on captopril. The percent change in mean blood pressure during the 2 weeks of treatment with enalapril (−35.6±4.0 SE%) was similar to that with captopril (−35.8±2.8%). S-Cr did not change in both groups, while S-K increased significantly from 3.9±0.2 to 5.2±0.2 mEq/l on enalapril and from 3.6±0.2 to 4.2±0.1 mEq/l on captopril. S-K at the second week was significantly higher in the enalapril than in the captopril group. The maximum S-Cr concentration during the treatment was correlated with the corresponding S-K concentration similarly in both groups. These results indicate that both enalapril and captopril increase S-K without deterioration of renal function in patients with malignant hypertension and that the way these drugs are used in clinical practice may be more likely to result in elevated S-K with enalapril.
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Tsuchihashi, T., Abe, I., Tsukashima, A. et al. Comparison of effects of enalapril and captopril on serum potassium concentration in the treatment of malignant hypertension. Cardiovasc Drug Ther 6, 495–498 (1992). https://doi.org/10.1007/BF00055607
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DOI: https://doi.org/10.1007/BF00055607