Summary
A double-blind, randomized crossover study was performed in 21 patients with essential arterial hypertension. Nitrendipine 20 mg o.d. and lisinopril 20 mg o.d. were given in a randomized order during a period of each 8 weeks. Nitrendipine and lisinopril decreased systolic and mean arterial blood pressure to a similar level without a significant increase in heart rate. The mean diastolic blood pressure was smaller with the lisinopril treatment than with the nitrendipine treat. The blood pressure decrease was maintained in the sitting and standing position. Furthermore, only nitrendipine decreased the pulsatility index at the tibial posterior arteries, while lisinopril did not influence it significantly. This finding means that mechanisms other than the blood-pressure lowering effect are involved in the decrease of the pulsatility index.
Similar content being viewed by others
References
Safar ME, Laurent SL, Bouthier JD, et al. Effect of converting enzyme inhibitors on hypertensive large arteries in humans. J Hypertens 1986;4(Suppl 5):S285-S289.
Hulthen UL, Katzman PL. Review of long-term trials with nitrendipine. J Cardiovasc Pharmacol 1988;12(Suppl 4): S11-S15.
Safar ME, Bouthier JA, Levenson JA, Simon AC. Peripheral large arteries and the reponse to antihypertensive treatment. Hypertension 1983;5(Suppl III):63–68.
Essandoh LK, Duprez D, Shepherd JT. Postural cardiovascular reflexes: Comparison of responses of forearm and calf resistance vessels. J Appl Physiol 1987;63:1801–1805.
Shepherd JT, Duprez DA, Essandoh LK. Neurogenic control of blood flow in human skeletal muscles. In: Vanhoutte PM, ed. Vasodilation: Vascular smooth muscle peptides, autonomic nerves and endothelium. New York: Raven Press, 1988:289–297.
Gosling RG, King DH. Processing arterial Doppler signals for clinical data. In: De Vlieger M, Homes JH, Kazner E et al., eds. Handbook of clinical ultrasound. New York: John Wiley & Sons, 1978:613–646.
Rocella EJ, Bowler AE, Horam M. Epidemiologic considerations in defining hypertension. Med Clin North Am 1987;71:785–801.
Duprez D, Lefebvre R, De Backer T, et al. Influence of nebivolol on the cardiovascular hemodynamics during postural changes and isometric exercise. Cardiovasc Drugs Ther 1991;5:709–718.
Evens RG. Doppler sonographic imaging of the vascular system. JAMA 1991;265:2382–2387.
Yao JS, Flin WR, Bergan JJ. Non-invasive vascular diagnostic testing: Techniques and clinical applications. Prog Cardiovasc Dis 1984;26:459–494.
Nichols WW, O'Rourke MF. Contours of pressure and flow waves in arteries. In: Nichols WW, O'Rourke MF, eds. McDonald's blood flow in arteries, 3rd ed. London: Edward Arnold Public, 1990:217–250.
Hills M, Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol 1979;8:7–20.
Caro CG, Fish PJ, Goss DE, et al. Effect of isosorbide dinitrate on the pattern of arterial blood flow in healthy human subjects. Clin Sci 1990;79:215–220.
Gangar KF, Vyas S, Whitehead M, et al. Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet 1991;338:839–842.
Simon AC, Safar ME, Levenson JA, et al. An evaluation of large arteries compliance in man. Am J Physiol 1979;5: H550-H554.
Safar ME, Simon AC, Levenson JA. Structural changes of large arteries in sustained essential hypertension. Hypertension 1984;6(Suppl III):117–121.
O'Rourke MF. Systolic blood pressure: Arterial compliance and early wave reflection and their modification by antihypertensive therapy. J Human Hypertens 1989;3:47–52.
O'Rourke MF. Arterial stiffness, systolic blood pressure and logical treatment of arterial hypertension. Hypertension 1990;15:339–347.
Nayler WG. Second generation calcium antagonists as blood pressure lowering agents: The prevention of cardiac hypertrophy. In: Nayler WG, ed. Second generation of calcium antagonists. Berlin: Springer-Verlag, 1991:163–172.
Kazda S, Garthoff B, Luckhaus G. Mode of antihypertensive action of nitrendipine. J Cardiovasc Pharmacol 1984;6 (Suppl):S956-S962.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Duprez, D., De Buyzere, M., Brusselmans, F. et al. Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension. Cardiovasc Drug Ther 6, 399–402 (1992). https://doi.org/10.1007/BF00054188
Issue Date:
DOI: https://doi.org/10.1007/BF00054188