This case-control investigation, based on the Selected Cancers Study, assesses the association between cigarette smoking and nasopharyngeal cancer, a relatively rare neoplasm in the United States. Men who were diagnosed pathologically with nasopharyngeal cancer during 1984–88 were included as cases in the analysis if they were 15 to 39 years old in 1968, and lived in the areas covered by eight cancer registries in the US (n=113). Control men were selected by random-digit telephone dialing (n=1,910). Using logistic regression analysis with adjustment for potential confounding factors, it was found that relative to nonsmokers, the risks of nasopharyngeal cancer were 2.3 (95 percent confidence interval [CI]=1.3–4.0) and 1.4 (CI=0.8–2.6) for former and current smokers, respectively. Using pack-years as a measure, adjusted odds ratio (OR) estimates were 1.3, 1.8, 2.5, and 3.9 for smoking for less than 15, 15–29, 30–44, and 45 or more pack-years, respectively. When squamous cell carcinoma was used as an outcome, the smoking/nasopharyngeal-cancer association became stronger. The analysis did not show interactions between smoking and alcohol consumption, or prior nasal diseases. The results of this study suggest that cigarette smoking may be related to the occurrence of nasopharyngeal cancer (especially squamous cell carcinoma) among US men.
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Shanmugaratnam K, Tye CY, Goh EH, Chia KB. Etiological Factors in Nasopharyngeal Carcinoma: a Hospital-based, Retrospective, Case-control, Questionnaire Study. Lyon, France: International Agency for Research on Cancer, 1978; IARC Sci. Pub. No. 20: 199–212.
Armstrong RW, Armstrong MJ, Yu MC, Henderson BE. Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chinese. Cancer Res 1983; 43: 2967–70.
Lin TM, Chang HJ, Chen CJ, et al. Risk factors for nasopharyngeal carcinoma. Anticancer Res 1986; 6: 791–6.
Chen CJ, Liang KY, Chang YS, et al. Multiple risk factors of nasopharyngeal carcinoma: Epstein-Barr virus, malarial infection, cigarette smoking and familial tendency. Anticancer Res 1990; 10: 547–54.
Sriamporn S, Vatanasapt V, Pisani P, Yongchaiyudha S, Rungpitarangsri V. Environmental risk factors for nasopharyngeal carcinoma: a case-control study in northeastern Thailand. Cancer Epidemiol Biomarkers Prev 1992; 1: 345–8.
West S, Hildesheim A, Dosemeci M. Non-viral risk factors for nasopharyngeal carcinoma in the philippines: results from a case-control study. Int J Cancer 1993; 55: 722–7.
Yu MC, Ho JHC, Lai SH, Henderson BE. Cantonesestyle salted fish as a cause of nasopharyngeal carcinoma: report of a case-control study in Hong Kong. Cancer Res 1986; 46: 956–61.
Henderson BE, Louie E, Jing JSH, Buell P, Gardner MB. Risk factors associated with nasopharyngeal carcinoma. N Engl J Med 1976; 295: 101–6.
Lanier A, Bender T, Talbot M, et al. Nasopharyngeal carcinoma in Alaskan Eskimos Indians, and Aleuts: a review of cases and study of Epstein-Barr virus, HLA, and environmental risk factors. Cancer 1980; 46: 2100–6.
Mabuchi KM, Bross DS, KesslerII. Cigarette smoking and nasopharyngeal carcinoma. Cancer 1985; 55: 2874–6.
Nam JM, McLaughlin JK, Blot WJ. Cigarette smoking, alcohol, and nasopharyngeal carcinoma: a case-control study among U.S. Whites. JNCI 1992; 84: 619–22.
Chow WH, McLaughlin JK, Hrubec Z, Nam JM, Blot WJ. Tobacco use and nasopharyngeal carcinoma in a cohort of US veterans. Int J Cancer 1993; 55: 538–40.
The Selected Cancers Cooperative Study Group. The association of selected cancers with service in the US military in Vietman, III: Hodgkins disease, nasal cancer, nasopharyngeal cancer, and primary liver cancer. Arch Intern Med 1990; 150:2495–505.
Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol 1. The Analysis of Case-Control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.
Hosmer DJr, Lemeshow S. Applied Logistic Regression. New York, NY (USA): John Wiley & Sons, 1990.
Hopkins JM, Evans HJ. Cigarette smoke-induced DNA damage and lung cancer risks. Nature 1980; 283: 388–90.
Takahashi A, Iwasaki I, Ide G. Effects of minute amounts of cigarette smoke with or without nebulized N-nitroso-N-methylurethane on the respiratory tract of mice. Jpn J Cancer Res 1985; 76: 324–30.
Weston A, Willey JC, Modali R, et al. Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. Proc Natl Acad Sci USA 1989; 86: 5099–103.
Yang CP, Gallagher RP, Weiss NS, Band PR, Thomas DB, Russell DA. Differences in incidence rates of cancers of the respiratory tract by anatomic subsite and histologic type: an etiologic implication. JNCI 1989; 81: 1828–31.
Fukuda K, Shibata A. Exposure-response relationships between woodworking, smoking or passive smoking, and squamous cell neoplasms of the maxillary sinus. Cancer Causes Control 1990; 1: 165–8.
Bartsch H, Petruzzelli S, De Flora S, et al. Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a case-control multicenter study on lung cancer patients. Environ Health Perspect 1992; 98: 119–24.
Gosney JR, Butt SA, Gosney MA, Field JK. Exposure to cigarette smoke and expression of the protein encoded by the p53 gene in bronchial carcinoma. Ann N Y Acad Sci 1993; 686: 243–7.
Sobue T, Suzuki T, Fujimoto I, et al. Case-control study for lung cancer and cigarette smoking in Osaka, Japan: comparison with the results from Western Europe. Jpn J Cancer Res 1994; 85: 464–73.
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This study was supported, in part, by the Andrew G. Mellon Foundation.
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Zhu, K., Levine, R.S., Brann, E.A. et al. A population-based case-control study of the relationship between cigarette smoking and nasopharyngeal cancer (United States). Cancer Causes Control 6, 507–512 (1995). https://doi.org/10.1007/BF00054158
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DOI: https://doi.org/10.1007/BF00054158