We investigated the association between human leucocyte antigen (HLA) antigens and lymph node metastasis in 724 gastric cancer patients. Among patients who had poorly differentiated adenocarcinoma with or without HLA-DR4 antigen, lymph node metastasis was detected in 80.8 and 54.9%, respectively (relative risk (RR)=3.5, P = 0.0005, corrected P = 0.0285). It was more common in patients with a family history of cancer death (RR = 7.7). Among signet ring cell carcinoma patients with or without HLA-1152 antigen, lymph node metastasis was detected in 57.7 and 19.7%, respectively (RR =5.6, P=0.0001, corrected P=0.0086). It was more common in patients who were smokers (RR = 8.3). Our findings suggest that HLA-DR4 and HLA-1152 antigens are associated with lymph node metastasis in gastric cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ogoshi K, Tajima T, Mitomi T and Tsuji K, 1994, HLA-DR4 antigen and lymph node metastases in poorly differentiated adenocarcinoma of the stomach. Cancer, 73, 2250–2.
Japanese Research Society for Gastric Cancer, 1994, The general rules for the gastric cancer study in surgery and pathology. Part II. Histological classification of gastric cancer. Jap J Surg, 11, 140–5.
Gutierrez J, Lopez-Nevot MA, Cabrera T, et al. 1987, Class I and 11 HLA antigen distribution in normal mucosa, adenoma and colon carcinoma: relation with malignancy and invasiveness. Exp Clin Immunogen, 4, 144–52.
Stein B, Momburg F, Schwartz V, Schlag P, Moldenhauer G and Mohller P, 1988,Reduction or loss of HLA-A, B, C antigens in colorectal carcinoma appears not to influence survival. Br J Cancer, 57, 364–8.
Hilton DA and West KP, 1990, An evaluation of the prognostic significance of HLA-DR expression in gastric carcinoma. Cancer, 66, 1154–7.
Hayashi R and Ochiai T, 1986, HLA type and survival in gastric cancer. Cancer Res, 46, 3701–3.
Ma XC, Hattori T, Kushima R, Terata N and Kodama M, 1994, Expression of HLA-class II antigen in gastric carcinomas. Its relationship to histopathological grade, lymphocyte infiltration and five-year survival rate. Acta Oncol, 33, 187–90.
Lopez-Nevot MA, Esteban F, Ferron A, et al. 1989, HLA class I gene expression on human primary tumour and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinoma. Br J Cancer, 9, 221–6.
Gorelik E, Kim M, Duty L, Henion T and Galili U, 1993, Control of metastatic properties of BL6 melanoma cells by H-2Kb gene: immunological and nonimmunological mechanisms. Clin Exp Metastasis, 11, 439–52.
Boon T, 1993, Teaching the immune system to fight cancer. Sci Am, March, 32-9.
Van Pel A, Vessiere F and Boon T, 1983, Protection against two spontaneous mouse leukemias conferred by immunogenic variants obtained by mutagenesis. J Exp Med, 157, 1992–2001.
Fearon ER, Itaya T, Hunt B, Vogelstein B and Frost P, 1988, Induction in murine tumor of immunogenic tumor variants by transfection with a foreign gene. Cancer, 48, 2975–80.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogoshi, K., Tajima, T., Mitomi, T. et al. HLA antigens are candidate markers for prediction of lymph node metastasis in gastric cancer. Clin Exp Metast 14, 277–281 (1996). https://doi.org/10.1007/BF00053901
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00053901