Mixtures of CaO-SiO2-P2O5-CaF2 glass powders with 3.7 m ammonium phosphate solution give bioactive cements which can set in a few minutes and bond to living bone in a few weeks. In the present study, the mechanical strengths of the mixtures, which were held in 100% humidity at 37°C for 1 h and then soaked in a simulated body fluid (SBF) for 23 h, were investigated in terms of the glass composition. Their compressive strengths varied significantly with small changes in the CaO/SiO2/P2O5 ratios under a constant CaF2 content. Addition of CaF2 to a CaO-SiO2-P2O5 composition increased the compressive strength, whereas addition of MgO decreased it. The glass composition of CaO 47.1, SiO2 35.8, P2O5 17.1, CaF2 0.75 wt ratio gave the highest compressive strength among the compositions examined: 56 and 80 MPa, respectively, after soaking in the simulated body fluid for 23 h and 3 days. The variation of the compressive strength with the glass composition was well interpreted in terms of the amount of the hydroxyapatite formed at the intergranular spaces of the glass powders in the simulated body fluid.
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Yoshihara, S., Kokubo, T., Nishimura, N. et al. Effects of glass composition on compressive strength of bioactive cement based on CaO-SiO2-P2O5 glass powders. J Mater Sci: Mater Med 5, 123–129 (1994). https://doi.org/10.1007/BF00053331
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DOI: https://doi.org/10.1007/BF00053331